HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	32203420, 22558309, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1697
+	Hs
		896763 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Mm
		810562 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (2-1693): 0: 825: 55.96
+	Hs
		1050684 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Mm
		810542 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (2-1693): 0: 825: 55.96
+	Rn
		638964 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (2-1693): 0: 821: 55.73
+	Hs
		896912 DYN2_HUMAN (1-870): 0: 1057: 100.00		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		839720 DYN2_HUMAN (1-870): 0: 1057: 100.00		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Ce
		810574 DYN1_CAEEL (3-823): 0: 899: 61.86		VAV_CAEEL (1119-1627): 1.53e-67: 250: 15.66
+	Hs
		896780 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (1035-1211): 6.57e-11: 69.3: 28.26
+	Dm
		118279 DYN_DROME (6-842): 0: 928: 66.23		M9ND00_DROME (614-1224): 3.16e-15: 83.7: 13.68
+	Dm
		263714 DYN_DROME (6-842): 0: 928: 66.23		O61618_DROME (614-1224): 4.09e-15: 83.4: 14.33
+	Ce
		810584 DYN1_CAEEL (3-823): 0: 899: 61.86		Q9U2T9_CAEEL (586-1207): 1.3e-22: 108: 15.54