HitPredict

Interactor 1: ARP2 (P61160)
Actin-related protein 2 (Actin-like protein 2)
Gene: ACTR2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	20876399, unassigned1853
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 394 Hs			1 2527
+	Mm
		897015 ARP2_MOUSE (1-394): 0: 815: 100.00		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		891823 ACTB_HUMAN (1-388): 0: 574: 46.65		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		929893 ACTG_HUMAN (3-388): 0: 573: 46.37		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		930084 ACTH_HUMAN (1-388): 0: 569: 45.62		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		932198 ACTC_HUMAN (2-388): 0: 569: 46.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		932992 ACTS_HUMAN (2-388): 0: 569: 46.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		915405 ACTA_HUMAN (3-388): 0: 567: 45.86		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		892172 ACTB_MOUSE (1-388): 0: 574: 46.65		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		929787 ACTG_MOUSE (3-388): 0: 573: 46.37		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Zm
		73747 B4F989_MAIZE (2-388): 0: 565: 46.00		K7V4X2_MAIZE (795-1429): 1.29e-103: 363: 14.69
+	Hs
		201296 ACTG_HUMAN (3-388): 0: 573: 46.37		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83