HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.900

Property	Details
Experiments	21900206, 15834155, 16696976, unassigned3799
Identification Methods	two hybrid, pull down, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0055037 - recycling endosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1721
+	Mm
		810562 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (1-1721): 0: 846: 94.65
+	Hs
		1050684 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (1-1721): 0: 879: 100.00
+	Mm
		810542 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (1-1721): 0: 846: 94.65
+	Rn
		638964 DYN1_RAT (1-846): 0: 994: 78.57		ITSN1_RAT (1-1721): 0: 832: 94.25
+	Hs
		896907 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (1-1720): 0: 693: 55.48
+	Ce
		810574 DYN1_CAEEL (3-823): 0: 899: 61.86		VAV_CAEEL (1131-1566): 1.67e-66: 247: 17.89
+	Hs
		839720 DYN2_HUMAN (1-870): 0: 1057: 100.00		EPS15_HUMAN (508-930): 2.61e-12: 74.3: 12.03
+	Hs
		896780 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (1079-1218): 3.14e-09: 63.9: 28.57
+	Hs
		896912 DYN2_HUMAN (1-870): 0: 1057: 100.00		EP15R_HUMAN (555-929): 6.12e-09: 63.1: 12.12
+	Hs
		593970 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (895-1055): 6.46e-09: 62: 27.75
+	Dm
		118279 DYN_DROME (6-842): 0: 928: 66.23		M9ND00_DROME (706-1252): 1.05e-14: 82: 14.91
+	Dm
		263714 DYN_DROME (6-842): 0: 928: 66.23		O61618_DROME (703-1252): 1.01e-14: 82: 14.73
+	Ce
		810584 DYN1_CAEEL (3-823): 0: 899: 61.86		Q9U2T9_CAEEL (678-1242): 2.75e-20: 100: 13.32
+	Dm
		95602 DYN_DROME (6-842): 0: 928: 66.23		E3CTP7_DROME (25-165): 1.1e-10: 68.8: 22.37