HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	32786267, 37071682, 16620772
Identification Methods	pull down, cross-linking study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~ThiF
Common GO terms	GO:0005654 - nucleoplasm GO:0016925 - protein sumoylation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 95 Hs			1 640
+	Hs
		879160 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Hs
		928217 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Hs
		102176 SUMO5_HUMAN (1-93): 1.8e-34: 115: 44.33		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Rn
		70077 SUMO3_RAT (1-94): 2.04e-42: 135: 95.75		B1WC32_RAT (1-640): 0: 693: 94.38
+	Dm
		332537 O97102_DROME (1-94): 1.24e-37: 123: 68.09		Q7KUA4_DROME (2-631): 0: 569: 46.11
+	Sp
		140839 PMT3_SCHPO (7-93): 4.62e-37: 122: 50.58		UBA2_SCHPO (9-627): 7.86e-175: 513: 34.59
+	Sc
		854615 SMT3_YEAST (3-94): 4.25e-31: 106: 42.39		UBA2_YEAST (3-640): 2.21e-168: 496: 33.33
+	Hs
		607044 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Rn
		1137284 SUMO3_RAT (1-94): 2.04e-42: 135: 95.75		UBA1_RAT (6-634): 8.82e-60: 218: 12.81