HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	17353931, 28292943, 19490896, 15831487, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 392
+	Hs
		906912 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		792951 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		798748 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		906981 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		730342 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		792936 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		907118 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Hs
		903081 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Mm
		907215 PRS8_MOUSE (1-406): 1.42e-136: 398: 100.00		PRP19_MOUSE (89-204): 4.15e-13: 72.4: 33.06
+	Sc
		703933 PRS7_YEAST (84-391): 1.53e-111: 336: 54.87		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		798631 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		730231 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		913344 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		913238 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Sc
		744670 PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Sc
		860037 PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		903094 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88