HitPredict

Interactor 1: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Interactor 2: Q8TD98 (Q8TD98)
MLL/AF4 fusion protein
Gene: Q8TD98

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	20153263
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AF-4~AF-4
Common GO terms	GO:0010468 - regulation of gene expression
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 624
+	Hs
		908262 AFF1_HUMAN (1-1210): 5.21e-124: 414: 100.00		AFF1_HUMAN (36-624): 7.77e-44: 171: 76.57
+	Hs
		908271 AFF1_HUMAN (1-1210): 5.21e-124: 414: 100.00		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		908295 AFF1_HUMAN (1-1210): 5.21e-124: 414: 100.00		AFF4_HUMAN (38-624): 1.09e-23: 108: 28.26
+	Hs
		1041615 AFF4_HUMAN (10-1208): 4.37e-90: 318: 33.78		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		590235 MUC1_HUMAN (48-1024): 2.81e-44: 177: 9.21		MUC1_HUMAN (1-432): 3.32e-27: 119: 9.24
+	Hs
		1041564 Q8TD98_HUMAN (341-831): 4.39e-32: 135: 90.12		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		1041568 TITIN_HUMAN (98-995): 5.6e-15: 82.8: 9.39		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		161491 KMT2D_HUMAN (23-1021): 4.87e-11: 69.7: 10.24		KMT2C_HUMAN (5-533): 1.48e-27: 121: 12.64
+	Hs
		161451 KMT2D_HUMAN (23-1021): 4.87e-11: 69.7: 10.24		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		1041613 RERE_HUMAN (24-836): 6.92e-11: 69.3: 8.88		KMT2A_HUMAN (6-146): 1.05e-24: 112: 90.48
+	Hs
		161525 KMT2D_HUMAN (23-1021): 4.87e-11: 69.7: 10.24		KMT2B_HUMAN (21-151): 8.3e-24: 109: 39.42
+	Hs
		1454810 RERE_HUMAN (24-836): 6.92e-11: 69.3: 8.88		KMT2B_HUMAN (21-151): 8.3e-24: 109: 39.42
+	Mm
		1455913 PCLO_MOUSE (6-936): 8.38e-20: 98.6: 10.27		PCLO_MOUSE (77-618): 2.71e-14: 79: 10.70
+	Hs
		1129637 MDC1_HUMAN (84-869): 9.51e-12: 72: 15.09		MICA3_HUMAN (132-611): 4.88e-21: 100: 11.35
+	Dm
		119660 M9PB30_DROME (494-1136): 1.24e-11: 72: 8.99		M9PB30_DROME (2-534): 1.87e-19: 95.5: 9.36
+	Hs
		1361951 TITIN_HUMAN (98-995): 5.6e-15: 82.8: 9.39		MYO16_HUMAN (124-469): 3.58e-11: 68.9: 12.71
+	Hs
		1361879 TITIN_HUMAN (98-995): 5.6e-15: 82.8: 9.39		TITIN_HUMAN (9-507): 3.82e-09: 62.2: 13.99
+	Hs
		1129588 MDC1_HUMAN (84-869): 9.51e-12: 72: 15.09		MDC1_HUMAN (33-623): 2.67e-12: 72.4: 9.65
+	Dm
		1305273 Q8IQA6_DROME (5-1028): 2.33e-11: 70.9: 9.37		Q9VLS7_DROME (18-624): 5.18e-10: 65.1: 8.82