Protein: AFF4
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)

Gene: AFF4
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q9UHB7

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0001650 - fibrillar center
GO:0005654 - nucleoplasm
GO:0007286 - spermatid development
GO:0008023 - transcription elongation factor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

898015

CDK9
Cyclin-dependent kinase 9

16

14

Small-scale

0.986

High

1040765

ENL
Protein ENL

7

17

Small-scale

0.970

High

251670

CCNT1
Cyclin-T1

7

2

Small-scale

0.967

High

137345

ELL2
RNA polymerase II elongation factor ELL2

7

16

Small-scale

0.966

High

839930

AF9
Protein AF-9

6

10

Small-scale

0.946

High

252269

CCNT2
Cyclin-T2

4

2

High-throughput

0.903

High

936626

ELL
RNA polymerase II elongation factor ELL

4

12

High-throughput

0.903

High

1437949

ELL3
RNA polymerase II elongation factor ELL3

4

12

High-throughput

0.892

High

908295

AFF1
AF4/FMR2 family member 1

2

18

Small-scale

0.811

High

1335398

CAMKV
CaM kinase-like vesicle-associated protein

3

4

High-throughput

0.765

High

1385966

EAF2
ELL-associated factor 2

4

3

High-throughput

0.699

High

1394900

EAF1
ELL-associated factor 1

4

3

High-throughput

0.699

High

1209764

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.692

High

325153

HEXI1
Protein HEXIM1

3

2

High-throughput

0.667

High

1317054

FAM9A
Protein FAM9A

3

1

High-throughput

0.667

High

1434872

DEN2D
DENN domain-containing protein 2D

3

1

High-throughput

0.667

High

872045

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

4

High-throughput

0.662

High

1090960

TRAF2
TNF receptor-associated factor 2

2

5

High-throughput

0.633

High

732731

ARRB2
Beta-arrestin-2

2

1

High-throughput

0.628

High

846802

GRK6
G protein-coupled receptor kinase 6

1

3

High-throughput

0.618

High

1400522

CDK15
Cyclin-dependent kinase 15

1

6

High-throughput

0.618

High

443548

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.618

High

1025518

CDK5
Cyclin-dependent kinase 5

1

4

High-throughput

0.618

High

1452821

CDK12
Cyclin-dependent kinase 12

1

14

High-throughput

0.618

High

1041615

KMT2A
Histone-lysine N-methyltransferase 2A

2

20

Small-scale

0.611

High

139630

PESC
Pescadillo homolog

2

0

High-throughput

0.602

High

336038

MED26
Mediator of RNA polymerase II transcription subunit 26

2

2

High-throughput

0.601

High

998918

H31
Histone H3.1

2

17

High-throughput

0.584

High

1307811

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

9

High-throughput

0.578

High

1206018

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

17

High-throughput

0.576

High

49030

MED19
Mediator of RNA polymerase II transcription subunit 19

2

1

High-throughput

0.571

High

397155

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1369319

EDA
Ectodysplasin-A

2

4

High-throughput

0.558

High

401658

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.553

High

762066

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.553

High

1394710

WNK4
Serine/threonine-protein kinase WNK4

1

2

High-throughput

0.553

High

1433646

E41L1
Band 4.1-like protein 1

2

16

High-throughput

0.549

High

704560

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.536

High

1243877

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.536

High

1349232

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

4

High-throughput

0.536

High

1439297

E41L5
Band 4.1-like protein 5

1

16

High-throughput

0.536

High

1451814

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

1459000

DAXX
Death domain-associated protein 6

1

3

High-throughput

0.536

High

989158

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.523

High

1063678

GOGA2
Golgin subfamily A member 2

1

14

High-throughput

0.523

High

502167

H2AZ
Histone H2A.Z

1

9

High-throughput

0.515

High

595630

H15
Histone H1.5

1

11

High-throughput

0.515

High

1372331

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.515

High

1331770

JMY
Junction-mediating and -regulatory protein

1

0

High-throughput

0.513

High

1458272

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

140473

SDCB1
Syntenin-1

1

4

Small-scale

0.501

High

961231

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.489

High

1144909

RASA2
Ras GTPase-activating protein 2

1

4

High-throughput

0.489

High

1178108

RN151
RING finger protein 151

1

6

High-throughput

0.489

High

1290418

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.489

High

1325097

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

4

High-throughput

0.489

High

1331799

F133A
Protein FAM133A

1

1

High-throughput

0.489

High

1331873

SYT2
Synaptotagmin-2

1

3

High-throughput

0.489

High

1411084

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

4

High-throughput

0.489

High

1459768

E41L3
Band 4.1-like protein 3

1

16

High-throughput

0.489

High

129522

MEN1
Menin

1

5

High-throughput

0.479

High

141155

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

180953

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

191147

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

373416

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

474350

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.479

High

487856

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

520429

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

558471

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

697284

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

800152

COIL
Coilin

1

1

High-throughput

0.479

High

905254

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

1017278

H33
Histone H3.3

1

17

High-throughput

0.479

High

1035971

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

1088078

NFIA
Nuclear factor 1 A-type

1

18

High-throughput

0.479

High

1124431

ELOA1
Elongin-A

1

7

Small-scale

0.479

High

1128140

DHX8
ATP-dependent RNA helicase DHX8

1

4

High-throughput

0.479

High

1218902

TAF3
Transcription initiation factor TFIID subunit 3

1

15

High-throughput

0.479

High

1289691

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1313502

SMC5
Structural maintenance of chromosomes protein 5

1

14

High-throughput

0.479

High

1314469

SLX4
Structure-specific endonuclease subunit SLX4

1

15

High-throughput

0.479

High

1314721

SRRM1
Serine/arginine repetitive matrix protein 1

1

16

High-throughput

0.479

High

1336871

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

16

Small-scale

0.479

High

1364293

TOPB1
DNA topoisomerase 2-binding protein 1

1

11

High-throughput

0.479

High

1368512

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

1368664

KAT6A
Histone acetyltransferase KAT6A

1

11

High-throughput

0.479

High

1371761

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

Small-scale

0.479

High

1404625

NOTC4
Neurogenic locus notch homolog protein 4

1

10

High-throughput

0.479

High

1414611

DDX23
Probable ATP-dependent RNA helicase DDX23

1

4

High-throughput

0.479

High

1418634

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

6

High-throughput

0.479

High

1430622

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1437936

SP110
Sp110 nuclear body protein

1

19

High-throughput

0.479

High

1452458

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1459201

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1459769

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1057020

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.457

High

765975

BMI1
Polycomb complex protein BMI-1

1

8

High-throughput

0.445

High

1413641

MED10
Mediator of RNA polymerase II transcription subunit 10

1

1

High-throughput

0.445

High

409116

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.437

High

459787

PROF1
Profilin-1

1

6

Small-scale

0.437

High

958043

RAB14
Ras-related protein Rab-14

1

4

High-throughput

0.437

High

1133715

NFIX
Nuclear factor 1 X-type

1

19

High-throughput

0.437

High

1140994

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.437

High

1454764

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

1418925

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.426

High

1054155

BTK
Tyrosine-protein kinase BTK

1

7

High-throughput

0.407

High

640628

MK
Midkine

2

0

High-throughput

0.328

High

823921

PBX2
Pre-B-cell leukemia transcription factor 2

2

0

High-throughput

0.328

High

1219065

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.328

High

1123547

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

64145

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.279

Low

1433629

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.279

Low

522307

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

1306890

INLR1
Interferon lambda receptor 1

1

0

Small-scale

0.249

Low

516136

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025