Protein: AFF1
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)

Gene: AFF1
Organism: Homo sapiens
Interactions: 59
UniProt ID: P51825

Gene Ontology (top 5):
GO:0008023 - transcription elongation factor complex
GO:0010468 - regulation of gene expression
GO:0032783 - super elongation complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897662

CDK9
Cyclin-dependent kinase 9

15

15

Small-scale

0.985

High

908270

ENL
Protein ENL

8

20

Small-scale

0.970

High

839869

AF9
Protein AF-9

6

11

Small-scale

0.950

High

908293

ELL3
RNA polymerase II elongation factor ELL3

4

11

High-throughput

0.892

High

137323

ELL2
RNA polymerase II elongation factor ELL2

3

18

Small-scale

0.861

High

908262

AFF1
AF4/FMR2 family member 1

3

15

Small-scale

0.827

High

251546

CCNT1
Cyclin-T1

5

3

Small-scale

0.823

High

908295

AFF4
AF4/FMR2 family member 4

2

18

Small-scale

0.811

High

908266

ELL
RNA polymerase II elongation factor ELL

2

11

Small-scale

0.754

High

908284

CAMKV
CaM kinase-like vesicle-associated protein

2

4

High-throughput

0.726

High

908290

EAF1
ELL-associated factor 1

4

2

High-throughput

0.699

High

908285

Q8TD98
MLL/AF4 fusion protein

1

19

Small-scale

0.575

High

871907

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

3

High-throughput

0.574

High

908271

KMT2A
Histone-lysine N-methyltransferase 2A

2

20

Small-scale

0.574

High

908264

ARFP1
Arfaptin-1

2

1

High-throughput

0.553

High

908274

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.553

High

908281

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

9

Small-scale

0.535

High

259653

BRD4
Bromodomain-containing protein 4

2

15

Small-scale

0.533

High

324660

HEXI1
Protein HEXIM1

2

2

Small-scale

0.533

High

211551

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

9

Small-scale

0.501

High

189978

MOT7
Monocarboxylate transporter 7

1

3

High-throughput

0.489

High

335970

MED26
Mediator of RNA polymerase II transcription subunit 26

1

2

High-throughput

0.489

High

556905

MYH7
Myosin-7

1

3

High-throughput

0.489

High

908268

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.489

High

908273

HDAC1
Histone deacetylase 1

1

13

High-throughput

0.489

High

908283

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

4

High-throughput

0.489

High

908287

ZN526
Zinc finger protein 526

1

6

High-throughput

0.489

High

908292

E41L1
Band 4.1-like protein 1

1

16

High-throughput

0.489

High

908296

E41L3
Band 4.1-like protein 3

1

16

High-throughput

0.489

High

908263

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.470

High

181866

SMAD9
Mothers against decapentaplegic homolog 9

1

5

High-throughput

0.464

High

908276

H31T
Histone H3.1t

1

15

Small-scale

0.457

High

330774

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.437

High

446788

NPM
Nucleophosmin

1

4

Small-scale

0.437

High

543482

VDR
Vitamin D3 receptor

1

20

Small-scale

0.437

High

606462

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.437

High

612944

EGR1
Early growth response protein 1

1

12

High-throughput

0.437

High

616277

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.437

High

667222

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.437

High

684137

DDX6
Probable ATP-dependent RNA helicase DDX6

1

7

Small-scale

0.437

High

709047

NEC1
Neuroendocrine convertase 1

1

1

Small-scale

0.437

High

908265

AF10
Protein AF-10

1

6

Small-scale

0.437

High

908267

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

908272

TF65
Transcription factor p65

1

12

Small-scale

0.437

High

908275

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.437

High

908278

LARP7
La-related protein 7

1

6

Small-scale

0.437

High

908279

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.437

High

908280

CARM1
Histone-arginine methyltransferase CARM1

1

3

Small-scale

0.437

High

908282

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.437

High

908286

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

Small-scale

0.437

High

908288

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.437

High

908289

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

908291

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

11

Small-scale

0.437

High

908294

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.437

High

320389

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.251

Low

639365

5NTD
5'-nucleotidase

1

0

Small-scale

0.251

Low

908269

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

908277

Q2Q440
MLL/ENL fusion protein

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025