HitPredict

Interactor 1: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Interactor 2: SPTN4 (Q9H254)
Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)
Gene: SPTBN4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 2564
+	Hs
		224794 SIK2_HUMAN (2-396): 2.79e-111: 350: 25.47		ACTN4_HUMAN (60-639): 2.59e-113: 386: 39.93
+	Rn
		930653 AAPK1_RAT (4-383): 1.22e-108: 333: 27.32		ACTN4_RAT (60-639): 1.48e-112: 384: 39.11
+	Hs
		862669 MARK2_HUMAN (2-425): 5.51e-123: 377: 23.56		UTRN_HUMAN (45-2419): 1.2e-91: 336: 14.45
+	Hs
		224664 NEK4_HUMAN (8-271): 2.83e-49: 181: 40.91		ACTN4_HUMAN (60-639): 2.59e-113: 386: 39.93
+	Rn
		930635 AAPK1_RAT (4-383): 1.22e-108: 333: 27.32		Q6XD99_RAT (621-2550): 6.99e-58: 225: 17.11
+	Hs
		908854 NEK2_HUMAN (1-445): 4e-146: 425: 100.00		CP250_HUMAN (231-1097): 3.42e-20: 101: 9.39
+	Mm
		547377 KCC2D_MOUSE (6-391): 5.34e-110: 335: 23.01		DMD_MOUSE (237-2463): 2.65e-27: 124: 9.71
+	Rn
		591437 AAPK1_RAT (4-383): 1.22e-108: 333: 27.32		SPTN1_RAT (246-1234): 1.04e-26: 122: 16.02
+	Hs
		1093102 STK4_HUMAN (6-442): 2.44e-108: 330: 22.75		SPTN1_HUMAN (246-1234): 1.26e-26: 122: 16.22
+	Hs
		1414958 SIK2_HUMAN (2-396): 2.79e-111: 350: 25.47		CP250_HUMAN (231-1097): 3.42e-20: 101: 9.39
+	Hs
		547463 MARK2_HUMAN (2-425): 5.51e-123: 377: 23.56		DMD_HUMAN (246-1102): 8.83e-09: 63.7: 12.54
+	Hs
		555754 SIK2_HUMAN (2-396): 2.79e-111: 350: 25.47		ACTN1_HUMAN (1813-2278): 3.34e-10: 67.9: 10.04
+	Rn
		930659 AAPK1_RAT (4-383): 1.22e-108: 333: 27.32		ACTN1_RAT (1813-2278): 3.63e-10: 67.9: 10.04
+	Hs
		908992 NEK4_HUMAN (8-271): 2.83e-49: 181: 40.91		SPTN1_HUMAN (246-1234): 1.26e-26: 122: 16.22
+	Hs
		1117394 NEK10_HUMAN (7-275): 5.24e-37: 146: 32.98		SPTN1_HUMAN (246-1234): 1.26e-26: 122: 16.22
+	Hs
		908964 NEK4_HUMAN (8-271): 2.83e-49: 181: 40.91		DYST_HUMAN (971-1734): 2.67e-10: 68.7: 12.78