HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	33711283, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 2610
+	Mm
		808343 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NEDD4_MOUSE (2258-2608): 9.66e-121: 407: 19.89
+	Rn
		910358 1433E_RAT (1-255): 4.87e-154: 430: 100.00		NEDD4_RAT (2258-2608): 4.01e-119: 403: 20.11
+	Mm
		93264 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		E9PXB7_MOUSE (2255-2608): 3.94e-119: 401: 21.67
+	Hs
		909930 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Mm
		910302 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NED4L_MOUSE (2255-2608): 2.21e-116: 398: 21.67
+	Hs
		125318 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Sc
		712922 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RSP5_YEAST (2265-2608): 2.06e-105: 360: 20.86
+	Sc
		664848 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		RSP5_YEAST (2265-2608): 2.06e-105: 360: 20.86
+	Hs
		909564 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		909468 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	At
		788566 14333_ARATH (1-253): 3.45e-147: 413: 74.12		UPL2_ARATH (2424-2604): 7.84e-20: 100: 34.60