HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: CDK10 (Q15131)
Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)
Gene: CDK10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 360
+	Hs
		1068439 ACTBL_HUMAN (4-377): 0: 712: 87.97		CDK10_HUMAN (1-360): 4.23e-136: 393: 100.00
+	Hs
		625278 ACTB_HUMAN (4-377): 0: 598: 94.12		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		625338 ACTG_HUMAN (4-377): 0: 598: 94.39		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		625343 ACTS_HUMAN (1-377): 0: 598: 97.88		CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43
+	Hs
		891779 ACTB_HUMAN (4-377): 0: 598: 94.12		CDK10_HUMAN (1-360): 4.23e-136: 393: 100.00
+	Hs
		841152 ACTG_HUMAN (4-377): 0: 598: 94.39		CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91
+	Hs
		841154 ACTC_HUMAN (1-377): 0: 598: 98.41		CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91
+	Hs
		841156 ACTS_HUMAN (1-377): 0: 598: 97.88		CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91