Protein: WDR48
WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)

Gene: WDR48
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q8TAF3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317197

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

25

15

Small-scale

0.992

High

967159

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

13

11

Small-scale

0.981

High

1347129

WDR20
WD repeat-containing protein 20

10

19

Small-scale

0.977

High

275905

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

11

11

Small-scale

0.976

High

247387

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

6

11

Small-scale

0.952

High

1347159

FANCI
Fanconi anemia group I protein

3

1

Small-scale

0.861

High

1256829

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

5

5

Small-scale

0.718

High

1347135

R51A1
RAD51-associated protein 1

7

0

Small-scale

0.718

High

257911

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

5

High-throughput

0.691

High

287975

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

9

High-throughput

0.691

High

502066

H2AZ
Histone H2A.Z

1

9

High-throughput

0.691

High

899144

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.691

High

1007158

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.691

High

1066239

DMWD
Dystrophia myotonica WD repeat-containing protein

1

20

High-throughput

0.691

High

1121053

BOP1
Ribosome biogenesis protein BOP1

1

19

High-throughput

0.691

High

1122940

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

20

High-throughput

0.691

High

1163077

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.691

High

1347131

DDX54
ATP-dependent RNA helicase DDX54

1

19

High-throughput

0.691

High

1347160

WDR70
WD repeat-containing protein 70

1

15

High-throughput

0.691

High

1347161

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

9

High-throughput

0.691

High

1330813

TSYL6
Testis-specific Y-encoded-like protein 6

3

3

High-throughput

0.662

High

1347143

ATAD5
ATPase family AAA domain-containing protein 5

3

9

Small-scale

0.640

High

1239631

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

6

High-throughput

0.628

High

1252069

RN19B
E3 ubiquitin-protein ligase RNF19B

2

14

High-throughput

0.628

High

1347170

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

4

High-throughput

0.618

High

159760

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

6

High-throughput

0.618

High

1227102

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.618

High

1254739

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1347153

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.618

High

325939

UBR5
E3 ubiquitin-protein ligase UBR5

2

12

Small-scale

0.611

High

414258

P53
Cellular tumor antigen p53

2

6

High-throughput

0.611

High

946021

VSX2
Visual system homeobox 2

2

4

High-throughput

0.611

High

1347145

NEB2
Neurabin-2

2

7

High-throughput

0.611

High

911315

IMA5
Importin subunit alpha-5

2

9

High-throughput

0.601

High

508312

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

14

Small-scale

0.585

High

1347162

VSX1
Visual system homeobox 1

2

4

High-throughput

0.584

High

1347167

FBXL7
F-box/LRR-repeat protein 7

2

1

Small-scale

0.584

High

1347132

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

0

High-throughput

0.578

High

1204376

SGO1
Shugoshin 1

2

0

High-throughput

0.576

High

342970

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

High-throughput

0.575

High

1347155

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.561

High

710379

EPHA2
Ephrin type-A receptor 2

1

7

High-throughput

0.553

High

1257083

PAXI1
PAX-interacting protein 1

1

17

High-throughput

0.552

High

174260

ARHGA
Rho guanine nucleotide exchange factor 10

1

14

High-throughput

0.536

High

188011

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

10

High-throughput

0.536

High

230077

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.536

High

254191

CTND1
Catenin delta-1

1

15

High-throughput

0.536

High

270965

CLAP2
CLIP-associating protein 2

1

4

High-throughput

0.536

High

273437

KDM4A
Lysine-specific demethylase 4A

1

8

High-throughput

0.536

High

292020

CRTAP
Cartilage-associated protein

1

1

High-throughput

0.536

High

540054

BCR
Breakpoint cluster region protein

1

12

High-throughput

0.536

High

625513

CSK22
Casein kinase II subunit alpha'

1

18

High-throughput

0.536

High

656196

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.536

High

787763

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.536

High

854175

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

888644

YLPM1
YLP motif-containing protein 1

1

13

High-throughput

0.536

High

960495

PSME3
Proteasome activator complex subunit 3

1

3

High-throughput

0.536

High

963332

PFD3
Prefoldin subunit 3

1

4

High-throughput

0.536

High

976117

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.536

High

995157

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

997877

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.536

High

1029342

SET
Protein SET

1

3

High-throughput

0.536

High

1105061

TCOF
Treacle protein

1

20

High-throughput

0.536

High

1115309

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

1119971

CIRBP
Cold-inducible RNA-binding protein

1

15

High-throughput

0.536

High

1121828

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

18

High-throughput

0.536

High

1134294

IMB1
Importin subunit beta-1

1

7

High-throughput

0.536

High

1154401

STK11
Serine/threonine-protein kinase STK11

1

10

High-throughput

0.536

High

1181404

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1216385

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

1270309

SPT6H
Transcription elongation factor SPT6

1

5

High-throughput

0.536

High

1281504

CENPV
Centromere protein V

1

2

High-throughput

0.536

High

1286769

KAISO
Transcriptional regulator Kaiso

1

2

High-throughput

0.536

High

1328870

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.536

High

1347137

SAHH3
Adenosylhomocysteinase 3

1

6

High-throughput

0.536

High

1347138

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.536

High

1347146

IWS1
Protein IWS1 homolog

1

9

High-throughput

0.536

High

1347147

SPSB2
SPRY domain-containing SOCS box protein 2

1

15

High-throughput

0.536

High

1347156

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.536

High

1347157

GPN1
GPN-loop GTPase 1

1

2

High-throughput

0.536

High

1347169

NEB1
Neurabin-1

1

5

High-throughput

0.536

High

1347171

AP3M1
AP-3 complex subunit mu-1

1

5

High-throughput

0.536

High

1347172

NOP16
Nucleolar protein 16

1

2

High-throughput

0.536

High

1347173

USH1C
Harmonin

1

5

High-throughput

0.536

High

106317

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

156055

SOCS6
Suppressor of cytokine signaling 6

1

3

High-throughput

0.515

High

615573

NELFE
Negative elongation factor E

1

0

High-throughput

0.513

High

866384

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.513

High

1103834

TARB1
tRNA

1

0

High-throughput

0.513

High

1210840

DACT2
Dapper homolog 2

1

0

High-throughput

0.513

High

1244528

SHQ1
Protein SHQ1 homolog

1

0

High-throughput

0.513

High

1278380

TRM11
tRNA

1

0

High-throughput

0.513

High

1347134

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.513

High

1347144

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.513

High

1347154

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

1347158

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.513

High

1347166

ZN639
Zinc finger protein 639

1

0

High-throughput

0.513

High

1055946

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.501

High

1275914

PBIR2
PABIR family member 2

1

1

High-throughput

0.489

High

1347164

GPN3
GPN-loop GTPase 3

1

2

High-throughput

0.489

High

1347168

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

551167

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

131476

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.479

High

164821

UN13B
Protein unc-13 homolog B

1

6

High-throughput

0.479

High

260198

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

279190

ULK1
Serine/threonine-protein kinase ULK1

1

8

Small-scale

0.479

High

294059

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

321981

NFAT5
Nuclear factor of activated T-cells 5

1

9

Small-scale

0.479

High

340913

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.479

High

346094

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.479

High

372641

MYC
Myc proto-oncogene protein

1

20

Small-scale

0.479

High

412290

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

520214

ANDR
Androgen receptor

1

14

Small-scale

0.479

High

674255

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

681456

PSA3
Proteasome subunit alpha type-3

1

5

Small-scale

0.479

High

799317

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

831099

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

1026141

CLH1
Clathrin heavy chain 1

1

7

High-throughput

0.479

High

1106356

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

9

High-throughput

0.479

High

1109632

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

10

Small-scale

0.479

High

1113765

CUL3
Cullin-3

1

20

Small-scale

0.479

High

1280350

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1347133

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1347139

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1347140

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

Small-scale

0.479

High

1347141

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1347163

TBK1
Serine/threonine-protein kinase TBK1

1

12

Small-scale

0.479

High

1347165

XPO7
Exportin-7

1

8

High-throughput

0.479

High

279428

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

832319

ID1
DNA-binding protein inhibitor ID-1

1

0

Small-scale

0.458

High

1135744

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1279204

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

138858

STK25
Serine/threonine-protein kinase 25

1

13

High-throughput

0.445

High

344255

PTBP3
Polypyrimidine tract-binding protein 3

1

14

High-throughput

0.445

High

944000

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.445

High

1145287

RNPS1
RNA-binding protein with serine-rich domain 1

1

10

High-throughput

0.445

High

1278770

HDGR2
Hepatoma-derived growth factor-related protein 2

1

10

High-throughput

0.445

High

1347149

THUM3
tRNA

1

1

High-throughput

0.445

High

1347150

HIRP3
HIRA-interacting protein 3

1

2

High-throughput

0.445

High

1347151

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.445

High

380100

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.437

High

1347152

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

10

High-throughput

0.437

High

72969

B1AM27
Unc-13 homolog B

1

5

High-throughput

0.407

High

75502

B3KSH1
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.407

High

183952

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.407

High

189987

MOT7
Monocarboxylate transporter 7

1

4

High-throughput

0.407

High

1208263

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

1

High-throughput

0.407

High

1316529

Q8IZK2
Breast and ovarian cancer susceptibility protein

1

5

High-throughput

0.407

High

1347130

HUMMR
Protein MGARP

2

0

High-throughput

0.313

High

1347142

OPALI
Opalin

2

0

High-throughput

0.313

High

1347148

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.313

High

125961

SMAP
Small acidic protein

1

0

High-throughput

0.279

Low

1347136

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

287594

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

Small-scale

0.249

Low

1133793

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.232

Low

1347128

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025