HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: PLXA1 (Q9UIW2)
Plexin-A1 (Semaphorin receptor NOV)
Gene: PLXNA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030334 - regulation of cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1896
+	Hs
		925714 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		901031 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		545690 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		436563 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		951446 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		PLXA1_HUMAN (1-1896): 0: 2610: 100.00
+	Hs
		165187 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165182 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165185 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165155 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165146 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Hs
		165189 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		PLXB2_HUMAN (38-1893): 0: 1949: 32.31
+	Dm
		776907 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		PLXB_DROME (45-1109): 0: 848: 27.10
+	Dm
		819748 RAC2_DROME (1-196): 6.51e-76: 227: 53.06		PLXB_DROME (45-1109): 0: 848: 27.10
+	Hs
		925450 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		900707 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		915845 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SEM6D_HUMAN (8-543): 7.26e-123: 417: 15.57
+	Hs
		915952 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SEM4C_HUMAN (3-575): 5.72e-123: 411: 20.29
+	Hs
		441478 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		436125 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		MET_HUMAN (814-1212): 1.56e-103: 367: 25.80
+	Hs
		195972 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PLXB1_HUMAN (558-875): 1.91e-12: 75.2: 18.58