HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	29643511, 33853758
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 2610
+	Hs
		1357018 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		919762 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Hs
		919889 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		304110 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1294888 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		919834 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		919827 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		919867 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		919869 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125808 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125262 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125335 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		919860 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1056647 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		849331 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		919729 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		849311 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		919710 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		919732 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37
+	Hs
		919782 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HACE1_HUMAN (204-449): 1.11e-20: 102: 14.96