HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RN114 (Q9Y508)
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
Gene: RNF114

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 26186194, 28514442, 28625874, 29643511, 33961781, 19549727
Identification Methods affinity chromatography technology, enzymatic study, pull down, two hybrid, anti tag coimmunoprecipitation, two hybrid array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-RING_UBOX
Common GO terms GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0061630 - ubiquitin protein ligase activity
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 147
Hs

1 228
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Last updated: 15 Jul 2024