HitPredict

Interactor 1: COPA (P53621)
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
Gene: COPA

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29991511
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Coatomer_WDAD~WD40, CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1224 Hs			1 446
+	Hs
		921858 COPA_HUMAN (1-1224): 0: 1304: 100.00		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		1291942 WDR5B_HUMAN (439-624): 9.81e-19: 90.9: 10.55		GRWD1_HUMAN (1-446): 1.7e-119: 357: 100.00
+	Hs
		965194 WDR5_HUMAN (520-631): 1.42e-09: 63.1: 10.35		GRWD1_HUMAN (1-446): 1.7e-119: 357: 100.00
+	Hs
		773471 COPB2_HUMAN (196-996): 7.29e-62: 231: 13.86		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Sc
		793963 COPA_YEAST (195-490): 9.95e-54: 207: 13.66		TAF5_YEAST (250-445): 3.84e-31: 128: 16.75
+	Sc
		922098 COPA_YEAST (195-490): 9.95e-54: 207: 13.66		COPA_YEAST (298-445): 3.61e-23: 104: 17.57
+	Hs
		845264 LIS1_HUMAN (198-526): 4.28e-34: 138: 16.96		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		845250 LIS1_HUMAN (198-526): 4.28e-34: 138: 16.96		LIS1_HUMAN (257-445): 1.64e-41: 153: 17.60
+	Dm
		1463899 WDS_DROME (407-617): 1.99e-43: 164: 10.57		WDS_DROME (295-445): 5.51e-31: 124: 15.23
+	Hs
		965071 WDR5B_HUMAN (439-624): 9.81e-19: 90.9: 10.55		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Hs
		845346 LIS1_HUMAN (198-526): 4.28e-34: 138: 16.96		KTNB1_HUMAN (67-289): 2.75e-22: 101: 16.38
+	Mm
		988931 LIS1_MOUSE (359-573): 2.98e-16: 84.7: 13.10		LIS1_MOUSE (257-445): 1.15e-41: 154: 17.60
+	Hs
		964797 WDR5_HUMAN (520-631): 1.42e-09: 63.1: 10.35		WDR5_HUMAN (248-445): 1.74e-47: 167: 21.72
+	Ce
		1018610 COPB2_CAEEL (4-316): 3.99e-28: 125: 13.04		LIN53_CAEEL (41-247): 1.43e-20: 95.4: 10.33
+	Sc
		793939 COPB2_YEAST (2-266): 4.7e-18: 92.4: 12.55		TAF5_YEAST (250-445): 3.84e-31: 128: 16.75
+	Sc
		836070 COPB2_YEAST (2-266): 4.7e-18: 92.4: 12.55		COPA_YEAST (298-445): 3.61e-23: 104: 17.57
+	Ce
		1018728 LIS1_CAEEL (238-369): 1.77e-17: 88.2: 20.59		LIN53_CAEEL (41-247): 1.43e-20: 95.4: 10.33
+	Hs
		964891 WDR5_HUMAN (520-631): 1.42e-09: 63.1: 10.35		RBBP4_HUMAN (66-247): 7.51e-20: 93.1: 10.42
+	Hs
		965034 WDR5_HUMAN (520-631): 1.42e-09: 63.1: 10.35		WDR59_HUMAN (259-382): 1.25e-12: 72: 28.23