Protein: WDR59
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)

Gene: WDR59
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q6PJI9

Gene Ontology (top 5):
GO:0005765 - lysosomal membrane
GO:0005774 - vacuolar membrane
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0031669 - cellular response to nutrient levels

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

938231

SEC13
Protein SEC13 homolog

7

20

Small-scale

0.966

High

1245324

WDR24
GATOR2 complex protein WDR24

5

18

Small-scale

0.932

High

1245338

MIOS
GATOR2 complex protein MIOS

4

19

Small-scale

0.886

High

1245319

SEH1
Nucleoporin SEH1

3

18

Small-scale

0.847

High

1245315

NPRL2
GATOR1 complex protein NPRL2

3

6

Small-scale

0.827

High

1102335

GRB10
Growth factor receptor-bound protein 10

2

7

High-throughput

0.811

High

1007091

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.776

High

271361

DEPD5
GATOR1 complex protein DEPDC5

2

7

Small-scale

0.754

High

342922

HERC2
E3 ubiquitin-protein ligase HERC2

2

14

High-throughput

0.737

High

261419

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

18

High-throughput

0.726

High

1245316

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

5

3

Small-scale

0.718

High

945672

SESN2
Sestrin-2

4

6

Small-scale

0.708

High

1245327

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.691

High

1245318

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

1091884

NPRL3
GATOR1 complex protein NPRL3

3

6

Small-scale

0.633

High

217462

E41L2
Band 4.1-like protein 2

2

4

High-throughput

0.628

High

1101841

SKP2
S-phase kinase-associated protein 2

2

7

High-throughput

0.628

High

1245334

DOCK5
Dedicator of cytokinesis protein 5

2

3

High-throughput

0.628

High

1245337

MOG1
Ran guanine nucleotide release factor

2

1

High-throughput

0.628

High

1245344

CRYL1
Lambda-crystallin homolog

2

4

High-throughput

0.628

High

249152

DSCAM
Cell adhesion molecule DSCAM

1

6

High-throughput

0.625

High

1145478

RBBP5
Retinoblastoma-binding protein 5

1

19

High-throughput

0.618

High

1147922

SF3B3
Splicing factor 3B subunit 3

1

20

High-throughput

0.618

High

1245325

SIN3A
Paired amphipathic helix protein Sin3a

1

11

High-throughput

0.618

High

1245330

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

18

High-throughput

0.618

High

610726

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

1245314

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

14

High-throughput

0.618

High

1211528

SZT2
KICSTOR complex protein SZT2

2

1

Small-scale

0.611

High

1160971

NRF1
Nuclear respiratory factor 1

2

0

High-throughput

0.602

High

1245329

THTPA
Thiamine-triphosphatase

2

0

High-throughput

0.585

High

1245341

FAF1
FAS-associated factor 1

2

5

High-throughput

0.584

High

1245347

KPTN
KICSTOR complex protein kaptin

2

1

Small-scale

0.584

High

880161

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.578

High

277458

AVIL
Advillin

2

4

High-throughput

0.574

High

1024645

VIGLN
Vigilin

2

20

High-throughput

0.574

High

1245307

NUP54
Nucleoporin p54

2

5

High-throughput

0.574

High

1245309

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

2

6

High-throughput

0.574

High

1245312

TSYL6
Testis-specific Y-encoded-like protein 6

2

4

High-throughput

0.574

High

1245331

PITH1
PITH domain-containing protein 1

2

2

High-throughput

0.574

High

1245339

CRNN
Cornulin

2

4

High-throughput

0.574

High

177385

ARHGB
Rho guanine nucleotide exchange factor 11

2

17

High-throughput

0.571

High

1245313

TXND5
Thioredoxin domain-containing protein 5

2

14

High-throughput

0.558

High

1007714

RAE1L
mRNA export factor RAE1

1

20

High-throughput

0.553

High

945690

SESN3
Sestrin-3

1

6

Small-scale

0.550

High

900380

FXR2
RNA-binding protein FXR2

1

10

High-throughput

0.541

High

65851

CAST2
Cytosolic arginine sensor for mTORC1 subunit 2

1

3

Small-scale

0.536

High

188307

HDAC3
Histone deacetylase 3

1

20

High-throughput

0.536

High

258946

DNJA2
DnaJ homolog subfamily A member 2

1

15

High-throughput

0.536

High

593134

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.536

High

783603

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

15

High-throughput

0.536

High

1026433

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.536

High

1163922

UPP1
Uridine phosphorylase 1

1

1

High-throughput

0.536

High

1245306

TBA1A
Tubulin alpha-1A chain

1

17

High-throughput

0.536

High

1245311

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1245333

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1245345

PKHM1
Pleckstrin homology domain-containing family M member 1

1

3

Small-scale

0.536

High

296792

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

578669

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

1064574

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

280229

SC22B
Vesicle-trafficking protein SEC22b

1

2

High-throughput

0.489

High

326721

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

482253

PAEP
Glycodelin

1

1

High-throughput

0.489

High

1176999

INF2
Inverted formin-2

1

3

High-throughput

0.489

High

1245310

AN13A
Ankyrin repeat domain-containing protein 13A

1

5

High-throughput

0.489

High

1245321

LOXL4
Lysyl oxidase homolog 4

1

1

High-throughput

0.489

High

1245322

F167A
Protein FAM167A

1

1

High-throughput

0.489

High

1245326

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.489

High

1245336

BRMS1
Breast cancer metastasis-suppressor 1

1

6

High-throughput

0.489

High

1245343

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.489

High

1245346

NCOR2
Nuclear receptor corepressor 2

1

19

High-throughput

0.489

High

474760

VIME
Vimentin

1

6

High-throughput

0.481

High

1067442

EP300
Histone acetyltransferase p300

1

17

High-throughput

0.481

High

540511

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

Small-scale

0.479

High

562151

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

637578

FLNA
Filamin-A

1

14

High-throughput

0.479

High

730688

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

901324

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

901885

RAB9A
Ras-related protein Rab-9A

1

7

High-throughput

0.479

High

971661

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

1045415

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1140439

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1233287

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1245308

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1245317

ITFG2
KICSTOR complex protein ITFG2

1

1

Small-scale

0.479

High

1245323

KICS2
KICSTOR subunit 2

1

1

Small-scale

0.479

High

1245335

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

1245348

SESN1
Sestrin-1

1

6

Small-scale

0.479

High

1178211

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1245304

OLFM4
Olfactomedin-4

1

0

High-throughput

0.458

High

664878

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

2

High-throughput

0.445

High

1110474

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.445

High

285966

SF3B1
Splicing factor 3B subunit 1

1

10

High-throughput

0.437

High

372342

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.437

High

412117

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

768467

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

965034

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.437

High

1245340

XPO7
Exportin-7

1

15

High-throughput

0.437

High

844807

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1245305

PKHG7
Pleckstrin homology domain-containing family G member 7

1

14

High-throughput

0.407

High

1245332

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

289786

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1006263

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

1207218

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1221035

ANO1
Anoctamin-1

1

0

High-throughput

0.279

Low

1245320

TRM61
tRNA

1

0

High-throughput

0.279

Low

1245328

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1245342

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

377613

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025