HitPredict

Interactor 1: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Interactor 2: NUMBL (Q9Y6R0)
Numb-like protein (Numb-related protein) (Numb-R)
Gene: NUMBL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 609
+	Rn
		1015359 AP2M1_RAT (1-138): 1.83e-41: 144: 15.22		Q3MUI1_RAT (42-609): 2.8e-74: 250: 52.65
+	Hs
		889231 AP2S1_HUMAN (1-142): 6.21e-46: 147: 100.00		NUMB_HUMAN (42-609): 2.55e-68: 235: 46.87
+	Hs
		889321 AP2M1_HUMAN (1-138): 1.83e-41: 144: 15.22		NUMB_HUMAN (42-609): 2.55e-68: 235: 46.87
+	Mm
		977900 AP2S1_MOUSE (1-142): 6.21e-46: 147: 100.00		ANS1B_MOUSE (7-256): 3.1e-59: 216: 21.32
+	Hs
		1386732 AP2M1_HUMAN (1-138): 1.83e-41: 144: 15.22		GULP1_HUMAN (45-347): 1.37e-55: 192: 19.94
+	Hs
		269802 AP2M1_HUMAN (1-138): 1.83e-41: 144: 15.22		CAPON_HUMAN (68-316): 6.46e-39: 151: 19.05
+	Ce
		303789 AP2M_CAEEL (1-138): 2.48e-43: 149: 15.94		CED6_CAEEL (64-430): 7.46e-32: 131: 15.72
+	Hs
		922566 AP2S1_HUMAN (1-142): 6.21e-46: 147: 100.00		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		1022190 AP2M1_HUMAN (1-138): 1.83e-41: 144: 15.22		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		215911 AP2S1_HUMAN (1-142): 6.21e-46: 147: 100.00		SYNJ1_HUMAN (217-607): 6.28e-12: 70.9: 11.21
+	Hs
		215941 AP2M1_HUMAN (1-138): 1.83e-41: 144: 15.22		SYNJ1_HUMAN (217-607): 6.28e-12: 70.9: 11.21