Protein: AP2S1
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)

Gene: AP2S1
Organism: Homo sapiens
Interactions: 121
UniProt ID: P53680

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0009898 - cytoplasmic side of plasma membrane
GO:0016192 - vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

922601

AP2M1
AP-2 complex subunit mu

8

19

High-throughput

0.968

High

922564

AP2B1
AP-2 complex subunit beta

6

20

High-throughput

0.947

High

344658

AP2A1
AP-2 complex subunit alpha-1

5

20

Small-scale

0.934

High

323690

AP2A2
AP-2 complex subunit alpha-2

4

20

High-throughput

0.900

High

922570

AP1B1
AP-1 complex subunit beta-1

4

20

High-throughput

0.892

High

922598

STON2
Stonin-2

3

19

High-throughput

0.855

High

922585

AAGAB
Alpha- and gamma-adaptin-binding protein p34

10

2

Small-scale

0.758

High

839725

EPS15
Epidermal growth factor receptor substrate 15

5

13

High-throughput

0.720

High

922580

AAK1
AP2-associated protein kinase 1

5

10

High-throughput

0.716

High

922615

NECP2
Adaptin ear-binding coat-associated protein 2

5

6

High-throughput

0.716

High

922569

FCHO2
F-BAR domain only protein 2

4

4

High-throughput

0.697

High

922577

RBP1
RalA-binding protein 1

4

7

High-throughput

0.697

High

922578

ITSN1
Intersectin-1

4

9

High-throughput

0.697

High

922619

EP15R
Epidermal growth factor receptor substrate 15-like 1

4

13

High-throughput

0.697

High

363022

EGFR
Epidermal growth factor receptor

4

15

Small-scale

0.694

High

922593

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

3

3

High-throughput

0.662

High

922602

REPS1
RalBP1-associated Eps domain-containing protein 1

3

20

High-throughput

0.662

High

922613

BMP2K
BMP-2-inducible protein kinase

5

13

High-throughput

0.654

High

395746

ESR1
Estrogen receptor

3

8

High-throughput

0.650

High

922607

CCD32
Coiled-coil domain-containing protein 32

4

1

High-throughput

0.636

High

507124

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

9

High-throughput

0.628

High

883032

AMPH
Amphiphysin

2

4

High-throughput

0.628

High

922582

RUN3A
RUN domain-containing protein 3A

2

6

High-throughput

0.628

High

225788

AP1G1
AP-1 complex subunit gamma-1

1

20

Small-scale

0.618

High

507716

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

9

High-throughput

0.602

High

619634

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

922616

ITSN2
Intersectin-2

2

9

High-throughput

0.601

High

922626

SNX9
Sorting nexin-9

2

3

High-throughput

0.601

High

159576

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

4

Small-scale

0.584

High

922612

GPBL1
Vasculin-like protein 1

2

1

High-throughput

0.574

High

711285

SHC1
SHC-transforming protein 1

2

12

High-throughput

0.571

High

922610

RNF41
E3 ubiquitin-protein ligase NRDP1

1

4

Small-scale

0.552

High

889231

NUMB
Protein numb homolog

2

9

Small-scale

0.552

High

483052

CLCA
Clathrin light chain A

1

7

High-throughput

0.536

High

483313

CLCB
Clathrin light chain B

1

7

High-throughput

0.536

High

765284

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

922562

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.536

High

922563

GRB2
Growth factor receptor-bound protein 2

1

9

High-throughput

0.536

High

922567

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.536

High

922568

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

1

High-throughput

0.536

High

922572

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

922579

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.536

High

922595

NECP1
Adaptin ear-binding coat-associated protein 1

1

6

High-throughput

0.536

High

922600

ARHG1
Rho guanine nucleotide exchange factor 1

1

8

High-throughput

0.536

High

922606

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

6

High-throughput

0.536

High

561352

TDGF1
Protein Cripto

1

0

High-throughput

0.518

High

922609

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.515

High

646794

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.513

High

922556

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.513

High

922574

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

1

0

High-throughput

0.513

High

650661

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.489

High

922581

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

922596

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

922611

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

241182

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

281149

DPOLQ
DNA polymerase theta

1

1

High-throughput

0.479

High

400530

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

560339

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

565250

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

710139

EPHA2
Ephrin type-A receptor 2

1

7

Small-scale

0.479

High

774228

BASI
Basigin

1

1

High-throughput

0.479

High

791212

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

899793

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.479

High

904493

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

922560

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

922561

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

922571

CUL3
Cullin-3

1

3

High-throughput

0.479

High

922575

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

922583

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

922588

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

922590

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

High-throughput

0.479

High

922591

CUL9
Cullin-9

1

3

High-throughput

0.479

High

922592

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

922599

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

922603

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

922618

PAK5
Serine/threonine-protein kinase PAK 5

1

5

High-throughput

0.479

High

922620

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

922621

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

922622

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

922623

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

922625

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

3

Small-scale

0.479

High

378018

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

832884

CETN2
Centrin-2

1

0

High-throughput

0.458

High

893011

KHK
Ketohexokinase

1

0

High-throughput

0.458

High

922559

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.458

High

155653

FCHO1
F-BAR domain only protein 1

1

4

High-throughput

0.445

High

177190

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

4

High-throughput

0.445

High

215911

SYNJ1
Synaptojanin-1

1

4

High-throughput

0.445

High

254900

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

273657

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

8

High-throughput

0.445

High

529405

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

563468

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

922555

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

922558

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.445

High

922566

DAB2
Disabled homolog 2

1

11

High-throughput

0.445

High

922576

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.445

High

922604

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.445

High

922608

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

922617

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

4

High-throughput

0.445

High

105628

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

247761

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

315322

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

371550

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

588288

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

695015

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

767778

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

922565

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

922573

UBP2L
Ubiquitin-associated protein 2-like

1

5

High-throughput

0.437

High

922584

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.437

High

922586

CE128
Centrosomal protein of 128 kDa

1

3

High-throughput

0.437

High

922624

RNF11
RING finger protein 11

1

6

Small-scale

0.437

High

429574

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

922605

WRIP1
ATPase WRNIP1

1

2

High-throughput

0.407

High

922627

NUMBL
Numb-like protein

1

11

High-throughput

0.407

High

595358

H15
Histone H1.5

1

0

High-throughput

0.279

Low

922587

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

922614

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

922557

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

922589

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

922594

F181A
Protein FAM181A

1

0

High-throughput

0.249

Low

922597

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025