HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: BORG4 (Q9H3Q1)
Cdc42 effector protein 4 (Binder of Rho GTPases 4)
Gene: CDC42EP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 356
+	Hs
		564682 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		545611 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		1330288 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		892591 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		951333 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		894420 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		900891 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		BORG4_HUMAN (1-356): 3.59e-128: 373: 100.00
+	Hs
		564729 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		BORG2_HUMAN (2-229): 1.35e-56: 186: 24.21
+	Hs
		925198 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		564481 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		545325 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		960657 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		894571 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		BORG2_HUMAN (2-229): 1.35e-56: 186: 24.21
+	Hs
		892320 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		950927 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		893907 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		150121 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		BORG1_HUMAN (1-228): 1.31e-47: 162: 25.86
+	Hs
		900382 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		BORG5_HUMAN (3-227): 4.09e-53: 181: 32.16
+	Hs
		150124 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		BORG1_HUMAN (1-228): 1.31e-47: 162: 25.86
+	Hs
		894139 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		BORG3_HUMAN (1-56): 7.58e-15: 72.7: 60.71