HitPredict

Interactor 1: DYLT1 (P63172)
Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)
Gene: DYNLT1

Interactor 2: DYLT4 (Q5JR98)
Dynein light chain Tctex-type 4 (Protein N22.1) (Tctex-2-beta) (Tctex1 domain-containing protein 4)
Gene: DYNLT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Tctex-1~Tctex-1
Common GO terms	GO:0005737 - cytoplasm GO:0005868 - cytoplasmic dynein complex GO:0007018 - microtubule-based movement GO:0045505 - dynein intermediate chain binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 113 Hs			1 221
+	Hs
		1127236 DYT2B_HUMAN (2-110): 2.72e-36: 122: 29.09		DYLT4_HUMAN (1-221): 9.79e-109: 313: 100.00
+	Hs
		928647 DYLT1_HUMAN (1-113): 1.19e-51: 160: 100.00		DYT2B_HUMAN (91-220): 6.97e-51: 163: 33.33
+	Hs
		928580 DYLT1_HUMAN (1-113): 1.19e-51: 160: 100.00		DYLT1_HUMAN (113-218): 1.96e-48: 156: 19.81
+	Hs
		850536 DYLT3_HUMAN (1-113): 1.14e-46: 147: 54.39		DYT2B_HUMAN (91-220): 6.97e-51: 163: 33.33
+	Hs
		850527 DYLT1_HUMAN (1-113): 1.19e-51: 160: 100.00		DYLT3_HUMAN (111-218): 7.28e-46: 149: 18.52
+	Hs
		850524 DYLT3_HUMAN (1-113): 1.14e-46: 147: 54.39		DYLT3_HUMAN (111-218): 7.28e-46: 149: 18.52
+	Cr
		249526 O64980_CHLRE (1-113): 3.75e-46: 146: 61.40		O64980_CHLRE (113-218): 1.06e-45: 149: 25.47
+	Dm
		1276651 DYLT_DROME (5-113): 9.87e-45: 142: 70.64		DYLT_DROME (111-218): 1.61e-45: 148: 18.52
+	Dm
		1178518 DYLT_DROME (5-113): 9.87e-45: 142: 70.64		Q7K035_DROME (95-221): 1.47e-43: 146: 24.81
+	Dm
		1276661 DYLT_DROME (5-113): 9.87e-45: 142: 70.64		Q9VH45_DROME (107-219): 1.05e-43: 146: 33.33