HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: Q3UF73 (Q3UF73)
Ion transport domain-containing protein
Gene: Scn3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 201
+	Mm
		93276 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNAA_MOUSE (110-201): 4.72e-10: 60: 17.35
+	Mm
		93283 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (101-201): 7.17e-10: 59.7: 20.37
+	Mm
		93284 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (78-201): 6.76e-10: 59.7: 21.54
+	Mm
		69865 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (78-201): 2.26e-09: 58.1: 19.23
+	Mm
		93274 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (78-201): 3.76e-09: 57.7: 19.23
+	Hs
		1047217 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (123-199): 2.08e-11: 64.3: 21.69
+	Hs
		1055040 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		808340 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNAA_HUMAN (78-201): 3.37e-12: 66.6: 21.54
+	Hs
		808322 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN8A_HUMAN (78-201): 7.16e-10: 59.7: 21.54
+	Hs
		723839 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN1A_HUMAN (78-201): 1.12e-09: 59.3: 19.23
+	Hs
		808128 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Mm
		808349 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		Q3UF73_MOUSE (1-201): 4.74e-100: 289: 100.00
+	Hs
		125445 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		CAC1C_HUMAN (123-199): 2.08e-11: 64.3: 21.69
+	Hs
		723851 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN1A_HUMAN (78-201): 1.12e-09: 59.3: 19.23
+	Hs
		1055045 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		1079738 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN9A_HUMAN (78-201): 1.98e-09: 58.5: 20.00
+	Hs
		125457 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCN5A_HUMAN (110-201): 1.88e-09: 58.5: 20.41
+	Hs
		132322 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		CAC1A_HUMAN (125-201): 6.12e-11: 62.7: 21.69
+	Mm
		69867 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN2A_MOUSE (78-201): 2.26e-09: 58.1: 19.23
+	Mm
		808358 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN9A_MOUSE (78-201): 3.76e-09: 57.7: 19.23