Protein: MP2K7
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)

Gene: MP2K7, MAP2K7
Organism: Homo sapiens
Interactions: 174
UniProt ID: O14733

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004707 - MAP kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

153097

MK08
Mitogen-activated protein kinase 8

9

20

Small-scale

0.980

High

153119

M3K1
Mitogen-activated protein kinase kinase kinase 1

3

20

Small-scale

0.834

High

153090

MK01
Mitogen-activated protein kinase 1

3

20

Small-scale

0.825

High

153138

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.825

High

153098

MK09
Mitogen-activated protein kinase 9

3

20

Small-scale

0.820

High

153182

M3K20
Mitogen-activated protein kinase kinase kinase 20

2

17

Small-scale

0.789

High

153069

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

153070

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

153136

M3K11
Mitogen-activated protein kinase kinase kinase 11

2

15

Small-scale

0.778

High

153076

BRAF
Serine/threonine-protein kinase B-raf

2

20

Small-scale

0.768

High

153152

DUS19
Dual specificity protein phosphatase 19

2

9

Small-scale

0.768

High

153192

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

16

Small-scale

0.768

High

153163

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

17

Small-scale

0.754

High

153118

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

17

Small-scale

0.724

High

153191

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

1

High-throughput

0.705

High

71031

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.691

High

118643

AIP
AH receptor-interacting protein

1

18

High-throughput

0.691

High

153086

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.691

High

153106

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.691

High

153115

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.691

High

153122

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

153127

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.691

High

153133

DDB1
DNA damage-binding protein 1

1

5

High-throughput

0.691

High

153135

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.691

High

153143

VRK2
Serine/threonine-protein kinase VRK2

1

18

Small-scale

0.691

High

153158

CANB2
Calcineurin subunit B type 2

1

10

High-throughput

0.691

High

153169

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.691

High

153189

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

3

10

Small-scale

0.678

High

153114

DLK1
Protein delta homolog 1

3

5

High-throughput

0.667

High

153099

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.665

High

153042

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

17

Small-scale

0.647

High

153134

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.647

High

153166

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

16

Small-scale

0.647

High

153200

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

16

Small-scale

0.647

High

153188

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

20

Small-scale

0.646

High

153120

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

15

Small-scale

0.629

High

153149

TPC2
Two pore channel protein 2

2

2

High-throughput

0.628

High

153049

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

0

Small-scale

0.625

High

153040

GP182
G-protein coupled receptor 182

1

6

High-throughput

0.618

High

153091

NK3R
Neuromedin-K receptor

1

3

High-throughput

0.618

High

153105

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.618

High

153126

RCN2
Reticulocalbin-2

1

14

High-throughput

0.618

High

153147

DJC10
DnaJ homolog subfamily C member 10

1

4

High-throughput

0.618

High

153148

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

3

High-throughput

0.618

High

153041

CFLAR
CASP8 and FADD-like apoptosis regulator

1

9

Small-scale

0.618

High

153043

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.618

High

153046

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

153063

RASN
GTPase NRas

1

14

Small-scale

0.618

High

153130

KS6A2
Ribosomal protein S6 kinase alpha-2

1

17

High-throughput

0.618

High

153131

KS6A1
Ribosomal protein S6 kinase alpha-1

1

17

High-throughput

0.618

High

153141

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

153159

TRIB3
Tribbles homolog 3

1

16

Small-scale

0.618

High

153172

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

153186

ALK
ALK tyrosine kinase receptor

1

12

Small-scale

0.618

High

153037

XPO1
Exportin-1

2

15

High-throughput

0.611

High

153083

PROZ
Vitamin K-dependent protein Z

2

3

High-throughput

0.574

High

153128

I13R2
Interleukin-13 receptor subunit alpha-2

2

3

High-throughput

0.574

High

153190

LAMP3
Lysosome-associated membrane glycoprotein 3

2

3

High-throughput

0.574

High

153103

RBP2
E3 SUMO-protein ligase RanBP2

1

3

Small-scale

0.561

High

123417

PGRC1
Membrane-associated progesterone receptor component 1

2

3

Small-scale

0.558

High

153081

C4BPB
C4b-binding protein beta chain

2

1

High-throughput

0.558

High

153094

BASI
Basigin

2

3

High-throughput

0.558

High

153173

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.558

High

153145

ZDH17
Palmitoyltransferase ZDHHC17

1

11

Small-scale

0.553

High

153048

LPXN
Leupaxin

1

10

High-throughput

0.541

High

153112

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.541

High

50051

HACL2
2-hydroxyacyl-CoA lyase 2

1

3

High-throughput

0.536

High

153036

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.536

High

153038

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

153039

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.536

High

153047

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.536

High

153055

UBR5
E3 ubiquitin-protein ligase UBR5

1

18

High-throughput

0.536

High

153056

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

5

High-throughput

0.536

High

153057

ACSL3
Fatty acid CoA ligase Acsl3

1

1

High-throughput

0.536

High

153062

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

153065

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

153066

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

153067

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

5

High-throughput

0.536

High

153071

ANXA5
Annexin A5

1

7

High-throughput

0.536

High

153077

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.536

High

153078

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

5

High-throughput

0.536

High

153080

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.536

High

153084

TBG1
Tubulin gamma-1 chain

1

20

High-throughput

0.536

High

153087

PYR1
Multifunctional protein CAD

1

7

High-throughput

0.536

High

153096

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.536

High

153100

MAP1B
Microtubule-associated protein 1B

1

8

High-throughput

0.536

High

153104

F10A1
Hsc70-interacting protein

1

20

High-throughput

0.536

High

153108

KAD2
Adenylate kinase 2, mitochondrial

1

5

High-throughput

0.536

High

153110

DCAF7
DDB1- and CUL4-associated factor 7

1

8

High-throughput

0.536

High

153113

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

High-throughput

0.536

High

153116

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

2

High-throughput

0.536

High

153117

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

9

High-throughput

0.536

High

153123

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

153125

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.536

High

153129

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

153139

NU188
Nucleoporin NUP188

1

1

High-throughput

0.536

High

153144

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

High-throughput

0.536

High

153146

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

7

High-throughput

0.536

High

153155

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.536

High

153156

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

153157

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.536

High

153160

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.536

High

153161

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

153162

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

153165

NPAS1
Neuronal PAS domain-containing protein 1

1

14

High-throughput

0.536

High

153174

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

153178

PDLI7
PDZ and LIM domain protein 7

1

10

High-throughput

0.536

High

153181

APC11
Anaphase-promoting complex subunit 11

1

2

High-throughput

0.536

High

153185

AKP8L
A-kinase anchor protein 8-like

1

4

High-throughput

0.536

High

153187

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

High-throughput

0.536

High

153193

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.536

High

153195

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.536

High

153196

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.536

High

153079

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.518

High

153059

BCL10
B-cell lymphoma/leukemia 10

1

4

Small-scale

0.515

High

153072

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

153101

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.513

High

153107

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.513

High

153164

METH
Methionine synthase

1

0

High-throughput

0.513

High

153167

F174C
Protein FAM174C

1

0

High-throughput

0.513

High

153068

JUN
Transcription factor Jun

1

8

Small-scale

0.501

High

153074

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.501

High

118107

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

130344

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.489

High

153045

CALU
Calumenin

1

7

High-throughput

0.489

High

153052

FCN3
Ficolin-3

1

6

High-throughput

0.489

High

153053

ATP5H
ATP synthase subunit d, mitochondrial

1

1

High-throughput

0.489

High

153075

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.489

High

153082

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.489

High

153088

CALX
Calnexin

1

4

High-throughput

0.489

High

153109

ATPK
ATP synthase subunit f, mitochondrial

1

1

High-throughput

0.489

High

153121

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.489

High

153154

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.489

High

153170

CPVL
Probable serine carboxypeptidase CPVL

1

3

High-throughput

0.489

High

153197

PCDB6
Protocadherin beta-6

1

1

High-throughput

0.489

High

153198

PCDG5
Protocadherin gamma-A5

1

1

High-throughput

0.489

High

153199

TF3C3
General transcription factor 3C polypeptide 3

1

4

High-throughput

0.489

High

153089

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

13

Small-scale

0.484

High

2081

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.481

High

153044

WDR62
WD repeat-containing protein 62

1

14

Small-scale

0.479

High

153054

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.479

High

153058

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.479

High

153073

H2A1
Histone H2A type 1

1

5

High-throughput

0.479

High

153085

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

153092

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

153093

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.479

High

153111

1433E
14-3-3 protein epsilon

1

13

High-throughput

0.479

High

153124

CUL3
Cullin-3

1

11

High-throughput

0.479

High

153137

CL16A
Protein CLEC16A

1

5

High-throughput

0.479

High

153140

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.479

High

153142

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

153151

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

10

Small-scale

0.479

High

153153

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

1

Small-scale

0.479

High

153177

WDR6
tRNA

1

20

Small-scale

0.479

High

153179

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

153061

MOC2A
Molybdopterin synthase sulfur carrier subunit

1

0

High-throughput

0.458

High

153095

ARRC
Arrestin-C

1

10

High-throughput

0.457

High

841

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

56561

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.445

High

153060

MOC2B
Molybdopterin synthase catalytic subunit

1

2

High-throughput

0.445

High

153102

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

153175

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

153050

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.279

Low

153051

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.279

Low

153132

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.279

Low

153150

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

0

High-throughput

0.279

Low

153168

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

153171

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

153176

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

153180

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.279

Low

153183

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

153194

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

153064

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

153184

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024