HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007165 - signal transduction GO:0030336 - negative regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 196
+	Hs
		936282 AFAD_HUMAN (1-1824): 0: 1266: 100.00		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49
+	Hs
		955275 RAIN_HUMAN (244-974): 1.33e-96: 338: 16.02		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49
+	Hs
		988377 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		962066 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67
+	Hs
		978017 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		581060 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RAC2_HUMAN (1-196): 4.54e-77: 230: 53.57
+	Hs
		1015450 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOG_HUMAN (1-196): 3.36e-76: 228: 51.53
+	Hs
		466262 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOC_HUMAN (1-196): 8.71e-76: 227: 83.16
+	Hs
		953458 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RAC3_HUMAN (1-179): 5.41e-75: 225: 57.54
+	Hs
		955187 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49
+	Hs
		601296 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOQ_HUMAN (2-195): 6.74e-68: 207: 51.74
+	Hs
		126606 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		RHOD_HUMAN (7-182): 3.38e-66: 203: 53.98
+	Hs
		1015809 GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06		RHOG_HUMAN (1-196): 3.36e-76: 228: 51.53
+	Hs
		1439593 GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06		V9HWD0_HUMAN (2-195): 6.74e-68: 207: 51.74
+	Hs
		601455 GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06		RHOQ_HUMAN (2-195): 6.74e-68: 207: 51.74
+	Mm
		988891 DLG4_MOUSE (952-1591): 2.35e-24: 113: 11.13		RAC1_MOUSE (1-196): 1.47e-79: 236: 55.10
+	Mm
		1189508 DLG4_MOUSE (952-1591): 2.35e-24: 113: 11.13		Q3TLP8_MOUSE (1-196): 5.53e-75: 226: 49.77
+	Hs
		962343 DLG3_HUMAN (1009-1248): 4.09e-22: 106: 18.50		RHOA_HUMAN (1-196): 4.38e-78: 233: 83.67
+	Hs
		953602 DLG3_HUMAN (1009-1248): 4.09e-22: 106: 18.50		RAC3_HUMAN (1-179): 5.41e-75: 225: 57.54
+	Hs
		601396 DLG3_HUMAN (1009-1248): 4.09e-22: 106: 18.50		RHOQ_HUMAN (2-195): 6.74e-68: 207: 51.74