HitPredict

Interactor 1: CLD6 (P56747)
Claudin-6 (Skullin)
Gene: CLDN6

Interactor 2: ZO1 (Q07157)
Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	10601346, 37852424
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 220 Hs			1 1748
+	Hs
		337870 CLD7_HUMAN (1-209): 3.63e-85: 253: 41.43		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		942277 CLD8_HUMAN (1-220): 1.07e-83: 249: 44.00		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		138560 CLD5_HUMAN (1-220): 5.05e-82: 245: 52.73		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		194648 CLD3_HUMAN (3-220): 3.19e-78: 235: 56.62		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		154478 CLD4_HUMAN (1-193): 8.71e-78: 234: 63.21		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Hs
		348832 CLD1_HUMAN (1-209): 1.4e-76: 231: 41.91		ZO1_HUMAN (1-1748): 0: 924: 100.00
+	Mm
		811961 CLD8_MOUSE (1-220): 1.43e-82: 246: 44.00		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		204068 CLD4_MOUSE (1-209): 4.52e-82: 244: 60.77		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		236741 CLD5_MOUSE (1-220): 4.35e-81: 243: 53.18		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		312569 CLD1_MOUSE (1-209): 1.61e-81: 243: 45.24		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		811962 CLD7_MOUSE (1-209): 3.2e-81: 243: 43.33		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		811963 CLD6_MOUSE (1-220): 1.04e-78: 236: 87.73		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Mm
		811960 CLD3_MOUSE (3-220): 1.59e-76: 231: 57.80		ZO1_MOUSE (1-1748): 0: 871: 90.85
+	Hs
		325373 CLD1_HUMAN (1-209): 1.4e-76: 231: 41.91		ZO3_HUMAN (13-915): 5.18e-134: 443: 40.23
+	Mm
		312571 CLD1_MOUSE (1-209): 1.61e-81: 243: 45.24		ZO3_MOUSE (13-928): 4.14e-129: 429: 37.59
+	Mm
		312572 CLD1_MOUSE (1-209): 1.61e-81: 243: 45.24		ZO2_MOUSE (1086-1374): 4.86e-19: 96.5: 19.66
+	Hs
		348836 CLD1_HUMAN (1-209): 1.4e-76: 231: 41.91		INADL_HUMAN (60-583): 5.68e-19: 96.5: 18.77
+	Hs
		154482 CLD4_HUMAN (1-193): 8.71e-78: 234: 63.21		DLG1_HUMAN (259-512): 4.27e-17: 90: 16.67
+	Mm
		204069 CLD4_MOUSE (1-209): 4.52e-82: 244: 60.77		MPDZ_MOUSE (418-540): 2.32e-13: 78: 25.19
+	Mm
		312570 CLD1_MOUSE (1-209): 1.61e-81: 243: 45.24		MPDZ_MOUSE (418-540): 2.32e-13: 78: 25.19