HitPredict

Interactor 1: DSCR6 (P57055)
Protein ripply3 (Down syndrome critical region protein 6)
Gene: RIPPLY3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 190 Hs			1 197
+	Hs
		943470 DSCR6_HUMAN (1-190): 8.54e-104: 298: 100.00		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		943467 DSCR6_HUMAN (1-190): 8.54e-104: 298: 100.00		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		943469 DSCR6_HUMAN (1-190): 8.54e-104: 298: 100.00		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		943468 DSCR6_HUMAN (1-190): 8.54e-104: 298: 100.00		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1048165 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047834 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047995 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1048152 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		1047805 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		1047959 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Xl
		205898 BOWL_XENLA (30-119): 1.34e-35: 123: 29.90		TLE4_XENLA (2-191): 1.08e-101: 311: 69.27
+	Hs
		1061736 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1212330 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		Q5T3G3_HUMAN (2-197): 1.08e-99: 290: 61.43
+	Hs
		1206454 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		Q5JSZ1_HUMAN (2-192): 7.7e-95: 277: 63.11
+	Hs
		1061675 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1068906 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		Q5T3G3_HUMAN (2-197): 1.08e-99: 290: 61.43
+	Hs
		1068904 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		Q5JSZ1_HUMAN (2-192): 7.7e-95: 277: 63.11
+	Hs
		1047913 RIPP2_HUMAN (39-122): 1.02e-40: 136: 38.37		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62
+	Hs
		1047898 RIPP1_HUMAN (39-112): 2.91e-32: 115: 38.16		TLE2_HUMAN (2-149): 6.74e-80: 253: 71.62