HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 418
+	Hs
		461323 RIPK4_HUMAN (1-832): 0: 734: 100.00		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		461934 Q9H4D1_HUMAN (1-832): 0: 708: 92.31		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		573409 RIPK4_HUMAN (1-832): 0: 734: 100.00		ENPL_HUMAN (95-407): 8.59e-39: 150: 26.81
+	Hs
		461848 Q96T11_HUMAN (1-832): 0: 702: 92.07		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		468804 Q9H4D1_HUMAN (1-832): 0: 708: 92.31		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		573670 Q9H4D1_HUMAN (1-832): 0: 708: 92.31		ENPL_HUMAN (95-407): 8.59e-39: 150: 26.81
+	Hs
		1202101 ANKK1_HUMAN (321-643): 1.49e-47: 183: 18.21		HS904_HUMAN (1-418): 0: 548: 100.00
+	Hs
		461301 DAPK1_HUMAN (275-737): 1.15e-80: 285: 20.99		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		468274 ANK2_HUMAN (592-832): 3.09e-65: 240: 27.89		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		214374 RIPK2_HUMAN (31-276): 6.62e-54: 197: 44.94		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		461724 ANKK1_HUMAN (321-643): 1.49e-47: 183: 18.21		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		468611 ANKK1_HUMAN (321-643): 1.49e-47: 183: 18.21		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		468315 ANK3_HUMAN (659-832): 3.9e-46: 182: 32.57		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		462082 RIPK3_HUMAN (21-371): 4.09e-34: 139: 30.39		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		461449 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		HS90A_HUMAN (89-277): 7.79e-49: 178: 48.42
+	Hs
		468953 RIPK3_HUMAN (21-371): 4.09e-34: 139: 30.39		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		468344 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		HS90B_HUMAN (89-256): 3.15e-44: 165: 49.70
+	Hs
		1201994 ANKK1_HUMAN (321-643): 1.49e-47: 183: 18.21		H90B4_HUMAN (112-275): 1.79e-26: 112: 42.42