HitPredict

Interactor 1: SNP25 (P60880)
Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)
Gene: SNAP25

Interactor 2: STX19 (Q8N4C7)
Syntaxin-19
Gene: STX19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0031201 - SNARE complex GO:0031629 - synaptic vesicle fusion to presynaptic active zone membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 206 Hs			1 294
+	Mm
		204921 SNP25_MOUSE (1-206): 1.78e-64: 199: 100.00		STX1A_MOUSE (8-288): 1.56e-68: 216: 28.72
+	Bt
		746103 SNP25_BOVIN (1-206): 1.78e-64: 199: 100.00		STX1A_BOVIN (8-288): 8.71e-69: 216: 28.72
+	Rn
		746107 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX1A_RAT (8-288): 2.28e-68: 215: 29.08
+	Hs
		954395 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX1A_HUMAN (8-288): 8.65e-68: 214: 28.72
+	Hs
		954380 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX1B_HUMAN (8-288): 3.73e-67: 212: 28.01
+	Rn
		954423 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX1B_RAT (8-288): 3.73e-67: 212: 28.01
+	Ce
		194911 O62414_CAEEL (1-203): 1.09e-64: 200: 52.20		STX1A_CAEEL (2-288): 4.41e-66: 209: 27.08
+	Hs
		746187 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX2_HUMAN (24-288): 5.13e-65: 207: 26.32
+	Dm
		788351 SNP25_DROME (4-204): 2.9e-62: 194: 60.89		STX1A_DROME (28-289): 4.72e-64: 204: 25.10
+	Rn
		894399 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX2_RAT (29-283): 9.03e-62: 199: 27.34
+	Hs
		286640 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX11_HUMAN (1-290): 1.65e-58: 190: 36.43
+	Hs
		954387 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX4_HUMAN (8-289): 1.34e-56: 186: 27.47
+	Rn
		954429 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX4_RAT (8-289): 4.78e-53: 176: 25.00
+	Hs
		954389 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX3_HUMAN (1-281): 1.77e-52: 175: 29.08
+	Rn
		954428 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX3_RAT (1-281): 1.8e-51: 172: 28.72
+	Ce
		264318 O62414_CAEEL (1-203): 1.09e-64: 200: 52.20		STX3_CAEEL (2-287): 8.42e-50: 168: 19.86
+	Hs
		189488 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX7_HUMAN (58-280): 9.46e-48: 162: 17.26
+	Hs
		954401 SNP25_HUMAN (1-206): 1.78e-64: 199: 100.00		STX12_HUMAN (53-288): 5.32e-46: 157: 18.33
+	Rn
		108160 SNP25_RAT (1-206): 1.78e-64: 199: 100.00		STX12_RAT (53-283): 2.71e-44: 153: 18.30
+	Dm
		788362 SNP25_DROME (4-204): 2.9e-62: 194: 60.89		Q9VR90_DROME (4-287): 2.3e-44: 155: 10.94