HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: DSG1 (Q02413)
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)
Gene: DSG1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31478661
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1049
+	Hs
		601283 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		DSG2_HUMAN (2-1048): 0: 733: 32.40
+	Hs
		988489 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		DSG4_HUMAN (1-1049): 0: 749: 38.08
+	Hs
		1120819 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		DSG2_HUMAN (2-1048): 0: 733: 32.40
+	Hs
		988357 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		DSG2_HUMAN (2-1048): 0: 733: 32.40
+	Hs
		1015430 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		DSG2_HUMAN (2-1048): 0: 733: 32.40
+	Hs
		955153 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		DSG2_HUMAN (2-1048): 0: 733: 32.40
+	Hs
		646702 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		CADH3_HUMAN (26-766): 0: 568: 25.13
+	Hs
		618289 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		CADH2_HUMAN (19-489): 5.94e-64: 236: 18.71
+	Hs
		618239 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		CADH2_HUMAN (19-489): 5.94e-64: 236: 18.71
+	Hs
		618243 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		CADH2_HUMAN (19-489): 5.94e-64: 236: 18.71
+	Hs
		601246 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		DSC2_HUMAN (3-488): 3.22e-52: 200: 15.80
+	Hs
		555986 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		CADH1_HUMAN (19-417): 1.27e-58: 219: 20.77
+	Hs
		1037043 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		DSC2_HUMAN (3-488): 3.22e-52: 200: 15.80
+	Hs
		555989 RHOA_HUMAN (5-191): 2.51e-78: 233: 53.48		CADH1_HUMAN (19-417): 1.27e-58: 219: 20.77
+	Hs
		988295 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		DSC2_HUMAN (3-488): 3.22e-52: 200: 15.80
+	Hs
		1015377 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		DSC2_HUMAN (3-488): 3.22e-52: 200: 15.80
+	Hs
		955074 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		DSC2_HUMAN (3-488): 3.22e-52: 200: 15.80
+	Hs
		601290 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		DSC3_HUMAN (1-355): 7.08e-35: 145: 20.27
+	Hs
		1128550 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		DSC3_HUMAN (1-355): 7.08e-35: 145: 20.27
+	Hs
		955171 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		DSC3_HUMAN (1-355): 7.08e-35: 145: 20.27