HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PARD3 (Q8TEW0)
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Gene: PARD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0007163 - establishment or maintenance of cell polarity GO:0008104 - intracellular protein localization and 1 others more... GO:0030010 - establishment of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1356
+	Hs
		601386 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		1353272 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		988553 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		1015627 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		PARD3_HUMAN (1-1356): 0: 706: 100.00
+	Hs
		601396 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		DLG3_HUMAN (556-1119): 1.07e-27: 123: 13.64
+	Hs
		1015652 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		DLG3_HUMAN (556-1119): 1.07e-27: 123: 13.64
+	Hs
		601259 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Mm
		988891 RAC1_MOUSE (1-191): 1.15e-81: 242: 70.31		DLG4_MOUSE (540-699): 7.92e-23: 107: 27.98
+	Hs
		1090181 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		601286 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		988322 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		988627 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		MAGI1_HUMAN (413-780): 3.17e-16: 87: 15.48
+	Hs
		955103 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		PTN13_HUMAN (39-368): 1.89e-16: 87.8: 12.50
+	Hs
		955496 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		MAGI1_HUMAN (413-780): 3.17e-16: 87: 15.48
+	Hs
		1122344 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Dm
		828001 RAC1_DROME (1-191): 3.87e-79: 235: 69.27		SCRIB_DROME (554-719): 3.84e-13: 76.7: 22.49
+	Hs
		955091 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		ZO1_HUMAN (271-1335): 2.77e-12: 73.9: 9.16
+	Hs
		988360 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		1015432 RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96
+	Hs
		955158 CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00		SCRIB_HUMAN (458-668): 1.99e-09: 64.7: 26.96