HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	32707033, 31980649, 11773441, 20936779, unassigned2173
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 681
+	Hs
		1433523 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK6_HUMAN (1-681): 0: 627: 100.00
+	Hs
		1433556 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK5_HUMAN (1-676): 2.68e-169: 503: 45.03
+	Hs
		354527 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PAK4_HUMAN (1-675): 5.14e-140: 424: 42.82
+	Hs
		601185 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		AKT2_HUMAN (285-680): 6.87e-139: 417: 20.99
+	Hs
		354777 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK4_HUMAN (1-675): 5.14e-140: 424: 42.82
+	Hs
		354655 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PAK4_HUMAN (1-675): 5.14e-140: 424: 42.82
+	Hs
		605811 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		KAPCA_HUMAN (388-680): 3.28e-130: 390: 24.76
+	Hs
		728154 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		AKT1_HUMAN (349-680): 3.5e-132: 399: 23.10
+	Ce
		1041910 RAC1_CAEEL (1-191): 1.28e-82: 244: 65.97		PK1_CAEEL (161-680): 1.79e-126: 388: 33.58
+	Hs
		605631 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		KAPCA_HUMAN (388-680): 3.28e-130: 390: 24.76
+	Hs
		601265 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PAK1_HUMAN (3-174): 4.04e-37: 147: 19.08
+	Hs
		601267 RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94		PAK2_HUMAN (9-162): 1.74e-33: 137: 18.63
+	Hs
		1096499 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK1_HUMAN (3-174): 4.04e-37: 147: 19.08
+	Mm
		109225 RAC1_MOUSE (1-191): 1.15e-81: 242: 70.31		G5E884_MOUSE (3-174): 4.78e-37: 147: 19.08
+	Hs
		1097231 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK2_HUMAN (9-162): 1.74e-33: 137: 18.63
+	Hs
		988330 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PAK1_HUMAN (3-174): 4.04e-37: 147: 19.08
+	Mm
		312740 RAC1_MOUSE (1-191): 1.15e-81: 242: 70.31		PAK1_MOUSE (3-174): 3.22e-36: 145: 18.50
+	Hs
		297118 RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17		PAK3_HUMAN (3-171): 5.01e-31: 130: 16.67
+	Mm
		988904 RAC1_MOUSE (1-191): 1.15e-81: 242: 70.31		PAK2_MOUSE (9-162): 1.35e-33: 137: 19.26
+	Hs
		297098 RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31		PAK3_HUMAN (3-171): 5.01e-31: 130: 16.67