HitPredict

Interactor 1: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	28322253, 31241013, 39098523
Identification Methods	pull down, enzymatic study, two hybrid, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0006915 - apoptotic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 440
+	Hs
		982182 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108049 UB2E2_HUMAN (4-146): 2.35e-75: 224: 65.04		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108001 UB2E3_HUMAN (4-146): 1.4e-74: 222: 65.73		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		909315 UB2E1_HUMAN (4-146): 3.07e-73: 218: 65.04		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1295603 UB2D4_HUMAN (1-147): 8.97e-84: 243: 91.84		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		906699 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		982235 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		957128 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		957783 UBE2N_HUMAN (4-147): 5.95e-69: 206: 46.53		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Hs
		906733 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		MIB2_HUMAN (106-264): 3.56e-23: 104: 26.09
+	Hs
		982273 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		MIB2_HUMAN (106-264): 3.56e-23: 104: 26.09
+	Hs
		342798 UB2D1_HUMAN (1-147): 3.03e-83: 242: 88.44		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		342819 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		342813 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		957808 UBE2N_HUMAN (4-147): 5.95e-69: 206: 46.53		MIB2_HUMAN (106-264): 3.56e-23: 104: 26.09
+	Hs
		982187 UB2D2_HUMAN (1-147): 4.03e-83: 242: 97.28		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		957080 UB2D3_HUMAN (1-147): 6.9e-82: 239: 100.00		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		342814 UBE2N_HUMAN (4-147): 5.95e-69: 206: 46.53		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50