HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.911

The method score is based on:

Property Details
Experiments 32296183, 24981860, 26495868, unassigned1304, 20211142
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LID~LIM
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005667 - transcription regulator complex
GO:0006366 - transcription by RNA polymerase II
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 349
Hs

1 411
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Service provided by Combinatics, Japan

Last updated: 11Aug2025