HitPredict

Interactor 1: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	24981860, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 359
+	Hs
		961481 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL1_HUMAN (14-358): 2.62e-86: 266: 73.91
+	Mm
		961497 LDB1_MOUSE (1-411): 0: 760: 99.76		ISL1_MOUSE (14-358): 2.62e-86: 266: 73.91
+	Mm
		961503 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX5_MOUSE (26-356): 2.45e-57: 193: 27.04
+	Hs
		1287932 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX9_HUMAN (10-313): 5.12e-57: 192: 26.33
+	Hs
		895744 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		965479 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Mm
		965533 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO4_MOUSE (15-165): 1.76e-54: 178: 38.13
+	Mm
		1000507 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO3_MOUSE (27-148): 1.54e-26: 104: 40.16
+	Hs
		1287915 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO3_HUMAN (27-148): 1.54e-26: 104: 40.16
+	Hs
		682055 LDB1_HUMAN (1-411): 0: 760: 100.00		RBTN1_HUMAN (27-143): 3.29e-26: 103: 40.83
+	Mm
		923325 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX4_MOUSE (1-82): 2.25e-17: 84.6: 22.89
+	Hs
		1287917 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		253019 LDB1_HUMAN (1-411): 0: 760: 100.00		LMX1B_HUMAN (7-83): 3.21e-16: 81.2: 19.48
+	Mm
		312694 LDB1_MOUSE (1-411): 0: 760: 99.76		LMX1B_MOUSE (7-83): 2.68e-16: 81.2: 19.48
+	Hs
		1287935 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		877527 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX1_HUMAN (7-81): 3.85e-14: 75: 19.74
+	Mm
		988942 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX1_MOUSE (7-81): 3.61e-14: 75: 19.74
+	Mm
		895873 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX3_MOUSE (1-82): 6.47e-14: 74.2: 20.48
+	Hs
		1229355 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX8_HUMAN (7-81): 8.19e-13: 70.8: 20.00
+	Hs
		1287938 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX6_HUMAN (7-81): 1.16e-11: 67.3: 20.00