HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	9199174, 31871319, 15545284
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1025
+	Hs
		962352 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		CNKR1_HUMAN (351-693): 2.43e-66: 239: 21.04
+	Hs
		988798 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		SWP70_HUMAN (370-824): 7.3e-58: 212: 19.22
+	Hs
		962303 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		988547 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		466375 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Hs
		988444 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MRCKG_HUMAN (599-998): 1.14e-44: 178: 19.48
+	Hs
		962504 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PKHA5_HUMAN (318-1019): 2.96e-36: 151: 13.24
+	Hs
		988721 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		PKHA5_HUMAN (318-1019): 2.96e-36: 151: 13.24
+	Hs
		962148 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MRCKA_HUMAN (418-981): 1.19e-30: 133: 12.40
+	Hs
		988432 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MRCKA_HUMAN (418-981): 1.19e-30: 133: 12.40
+	Hs
		773156 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		MYH10_HUMAN (242-1024): 1.66e-21: 103: 8.45
+	Hs
		270791 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Hs
		270795 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Hs
		772724 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		270757 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Hs
		962466 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		SLK_HUMAN (194-1010): 4.74e-15: 82.5: 9.73
+	Hs
		270800 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		ROCK2_HUMAN (446-1018): 5.24e-17: 88.7: 11.81
+	Hs
		772743 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		466452 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		SLK_HUMAN (194-1010): 4.74e-15: 82.5: 9.73
+	Hs
		988695 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		TARA_HUMAN (645-1023): 9.99e-10: 65.1: 12.98