HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0030334 - regulation of cell migration GO:0031122 - cytoplasmic microtubule organization GO:0051893 - regulation of focal adhesion assembly GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1235
+	Rn
		97301 RHOA_RAT (1-193): 2.21e-80: 238: 99.48		CTRO_RAT (8-1230): 3.83e-148: 494: 15.83
+	Hs
		157168 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		CTRO_HUMAN (8-1230): 6.68e-144: 482: 15.44
+	Hs
		157213 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		CTRO_HUMAN (8-1230): 6.68e-144: 482: 15.44
+	Mm
		878608 RHOA_MOUSE (1-193): 2.21e-80: 238: 99.48		CTRO_MOUSE (8-1230): 5.12e-138: 465: 16.06
+	Mm
		878598 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		CTRO_MOUSE (8-1230): 5.12e-138: 465: 16.06
+	Hs
		962195 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MARK2_HUMAN (1-713): 1.36e-129: 418: 14.27
+	Hs
		988474 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MARK2_HUMAN (1-713): 1.36e-129: 418: 14.27
+	Hs
		317281 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		STK10_HUMAN (1-1000): 8.33e-115: 383: 32.25
+	Hs
		317287 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		STK10_HUMAN (1-1000): 8.33e-115: 383: 32.25
+	Hs
		962008 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PAK2_HUMAN (7-305): 1.19e-110: 359: 36.79
+	Hs
		988331 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		PAK2_HUMAN (7-305): 1.19e-110: 359: 36.79
+	Hs
		908091 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		KS6A3_HUMAN (2-342): 5.44e-96: 326: 21.43
+	Mm
		988877 RAC1_MOUSE (1-193): 7e-79: 235: 57.22		TNIK_MOUSE (29-323): 2.9e-55: 213: 40.59
+	Hs
		962148 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MRCKA_HUMAN (749-1226): 1.33e-46: 185: 15.59
+	Hs
		962678 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MRCKB_HUMAN (807-1222): 1.17e-46: 185: 14.78
+	Hs
		988432 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		MRCKA_HUMAN (749-1226): 1.33e-46: 185: 15.59
+	Hs
		962019 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ROCK1_HUMAN (585-1204): 2.92e-12: 73.5: 12.87
+	Hs
		988339 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		ROCK1_HUMAN (585-1204): 2.92e-12: 73.5: 12.87
+	Hs
		270791 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ROCK2_HUMAN (803-1233): 4.05e-11: 70: 13.76
+	Hs
		270795 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		ROCK2_HUMAN (803-1233): 4.05e-11: 70: 13.76