HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: NEK9 (Q8TD19)
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
Gene: NEK9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007346 - regulation of mitotic cell cycle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 979
+	Xl
		237423 O57468_XENLA (1-255): 1.71e-152: 426: 96.47		Q804T2_XENLA (2-481): 1.97e-140: 438: 19.54
+	Hs
		692031 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK3_HUMAN (2-481): 1.47e-137: 432: 20.00
+	Mm
		972206 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK3_MOUSE (2-481): 1.08e-135: 427: 19.59
+	Xl
		237424 O57468_XENLA (1-255): 1.71e-152: 426: 96.47		Q8QGV3_XENLA (2-477): 2.86e-131: 416: 19.67
+	Hs
		971697 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK2_HUMAN (1-446): 3.91e-129: 411: 19.46
+	Mm
		972209 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK2_MOUSE (1-446): 6.86e-127: 404: 18.57
+	Mm
		972294 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK1_MOUSE (2-476): 1.28e-125: 402: 18.33
+	Hs
		971464 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		STK4_HUMAN (29-485): 1.54e-128: 399: 22.17
+	Hs
		971474 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		STK3_HUMAN (27-485): 1.25e-128: 399: 19.87
+	Hs
		728147 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		AKT1_HUMAN (13-376): 2.6e-127: 395: 20.76
+	At
		1030844 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CDPK1_ARATH (6-410): 4.01e-124: 392: 19.61
+	At
		1030913 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (35-406): 1.12e-124: 389: 22.69
+	At
		840534 14333_ARATH (1-253): 3.47e-147: 413: 74.12		CIPKC_ARATH (35-406): 1.12e-124: 389: 22.69
+	At
		1379653 14337_ARATH (2-255): 7.77e-147: 412: 71.21		CIPKC_ARATH (35-406): 1.12e-124: 389: 22.69
+	At
		854983 14334_ARATH (4-255): 2.52e-145: 408: 73.62		CDPK1_ARATH (6-410): 4.01e-124: 392: 19.61
+	At
		840556 14335_ARATH (2-255): 3.06e-141: 398: 68.75		CDPK1_ARATH (6-410): 4.01e-124: 392: 19.61
+	Hs
		971902 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		NEK1_HUMAN (52-311): 4.49e-61: 229: 42.31
+	Hs
		908920 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		NEK4_HUMAN (52-361): 1.16e-56: 213: 36.78
+	Hs
		972069 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		PLK2_HUMAN (56-303): 6.22e-32: 135: 31.73