HitPredict

Interactor 1: HHEX (Q03014)
Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)
Gene: HHEX

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 270 Hs			1 197
+	Hs
		974243 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		974244 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		839732 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		882123 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		679098 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		882121 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		679096 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980663 HESX1_HUMAN (13-208): 1.22e-32: 120: 19.29		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		211837 TLX3_HUMAN (42-251): 4.93e-31: 118: 27.11		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		882122 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		679097 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		211839 TLX3_HUMAN (42-251): 4.93e-31: 118: 27.11		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		839735 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		882124 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		679101 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		211838 TLX3_HUMAN (42-251): 4.93e-31: 118: 27.11		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Dm
		484925 HMH2_DROME (134-260): 1.3e-36: 136: 33.07		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558366 UBX_DROME (16-198): 6.61e-31: 120: 19.89		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Ce
		137665 UNC4_CAEEL (93-262): 6.27e-34: 125: 22.35		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47
+	Ce
		137669 HM09_CAEEL (108-214): 5.55e-33: 119: 36.45		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47