HitPredict

Interactor 1: RUVB1 (Q03940)
RuvB-like protein 1 (RUVBL1) (EC 3.6.4.12) (TIP49-homology protein 1) (TIP49a homolog)
Gene: RVB1

Interactor 2: ARP8 (Q12386)
Actin-like protein ARP8
Gene: ARP8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	16429126, 30120252, 15607974, 16554755, 26831523, 31914392, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~TIP49
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006281 - DNA repair GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription and 1 others more... GO:0031011 - Ino80 complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 463 Sc			1 881
+	Sc
		1015551 RUVB2_YEAST (15-463): 0: 622: 41.15		ARP8_YEAST (1-881): 0: 789: 100.00
+	Hs
		1334078 RUVB1_HUMAN (2-461): 0: 682: 67.61		ARP8_HUMAN (264-881): 0: 559: 24.37
+	Mm
		888098 RUVB1_MOUSE (2-461): 0: 682: 67.83		ARP8_MOUSE (264-881): 0: 552: 24.07
+	Hs
		1334077 RUVB2_HUMAN (1-458): 0: 637: 41.09		ARP8_HUMAN (264-881): 0: 559: 24.37
+	Hs
		892123 RUVB1_HUMAN (2-461): 0: 682: 67.61		ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		930058 RUVB1_HUMAN (2-461): 0: 682: 67.61		ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		932463 RUVB1_HUMAN (2-461): 0: 682: 67.61		ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Sc
		887667 RUVB1_YEAST (1-463): 0: 682: 100.00		ACT_YEAST (730-877): 3.32e-52: 188: 15.66
+	Dm
		501453 RUVB1_DROME (15-461): 0: 648: 66.89		ACT5_DROME (730-877): 1.06e-54: 196: 15.06
+	Hs
		892121 RUVB2_HUMAN (1-458): 0: 637: 41.09		ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		930057 RUVB2_HUMAN (1-458): 0: 637: 41.09		ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		932462 RUVB2_HUMAN (1-458): 0: 637: 41.09		ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Sc
		887725 RUVB2_YEAST (15-463): 0: 622: 41.15		ACT_YEAST (730-877): 3.32e-52: 188: 15.66
+	Hs
		897003 RUVB1_HUMAN (2-461): 0: 682: 67.61		ARP2_HUMAN (405-619): 8.71e-18: 88.7: 21.88
+	Sc
		689377 RUVB1_YEAST (1-463): 0: 682: 100.00		ARP2_YEAST (405-619): 7.21e-15: 79.4: 18.75