HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: H2A3 (Q7L7L0)
Histone H2A type 3 (H2A-clustered histone 25)
Gene: H2AC25

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30804502, 34349018
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 130
+	Hs
		418924 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1B_HUMAN (1-130): 7.83e-68: 202: 99.23
+	Hs
		502295 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1_HUMAN (1-130): 6.57e-68: 202: 97.69
+	Hs
		634016 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1D_HUMAN (1-130): 7.66e-68: 202: 98.46
+	Hs
		979828 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A2A_HUMAN (1-130): 5.05e-68: 202: 97.69
+	Hs
		980093 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1C_HUMAN (1-130): 5.28e-68: 202: 99.23
+	Hs
		980214 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1J_HUMAN (1-128): 2.65e-67: 201: 96.88
+	Hs
		980152 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1H_HUMAN (1-128): 4.11e-67: 200: 97.66
+	Hs
		980176 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A1A_HUMAN (1-130): 6.15e-67: 200: 93.13
+	Hs
		979935 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A2B_HUMAN (1-130): 1.95e-66: 198: 94.62
+	Hs
		979742 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2A2C_HUMAN (1-130): 2.99e-65: 195: 96.15
+	Hs
		980243 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2AJ_HUMAN (1-126): 4.63e-65: 195: 95.24
+	Hs
		591579 H4_HUMAN (1-103): 1.39e-48: 151: 100.00		H2AX_HUMAN (1-130): 7.61e-64: 192: 88.81
+	Dm
		1014770 H4_DROME (1-103): 4.53e-48: 150: 99.03		H2A_DROME (17-125): 7.52e-60: 181: 89.91
+	Sc
		381770 H4_YEAST (18-103): 6.16e-41: 132: 90.70		H2A1_YEAST (16-127): 4.89e-53: 164: 81.25
+	Sc
		381771 H4_YEAST (18-103): 6.16e-41: 132: 90.70		H2A2_YEAST (16-127): 4.89e-53: 164: 81.25