HitPredict

Interactor 1: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17041588
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 743 Hs			1 913
+	Hs
		980599 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		980747 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		980682 TLE2_HUMAN (1-743): 0: 552: 100.00		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		929446 RACK1_HUMAN (534-741): 2.3e-49: 178: 18.18		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1043562 TBL1R_HUMAN (542-742): 7.44e-47: 176: 15.07		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		245601 TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		903209 WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1022817 STRN3_HUMAN (8-739): 1.97e-106: 344: 14.04		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		920959 GBB1_HUMAN (447-739): 3.21e-91: 290: 18.87		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		154680 GNB5_HUMAN (438-739): 1.62e-87: 282: 21.02		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		792982 LIS1_HUMAN (543-741): 6.74e-59: 206: 18.02		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		920958 GBB1_HUMAN (447-739): 3.21e-91: 290: 18.87		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		1043234 GBB4_HUMAN (368-617): 7.53e-41: 154: 18.18		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		903208 WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		1042655 NLE1_HUMAN (272-657): 1.52e-65: 227: 13.33		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		929445 RACK1_HUMAN (534-741): 2.3e-49: 178: 18.18		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		903207 WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		929443 RACK1_HUMAN (534-741): 2.3e-49: 178: 18.18		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		929444 RACK1_HUMAN (534-741): 2.3e-49: 178: 18.18		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		903206 WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37		CUL1_HUMAN (213-913): 0: 778: 30.16