HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CYTSA (Q69YQ0)
Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)
Gene: SPECC1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1117
+	Hs
		555659 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ACTN1_HUMAN (1009-1116): 3.98e-50: 194: 42.20
+	Hs
		224684 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ACTN4_HUMAN (1009-1116): 6.69e-48: 187: 41.28
+	Ce
		116175 SEM5_CAEEL (1-216): 5.16e-61: 192: 57.60		H2L2C8_CAEEL (1009-1116): 1.45e-49: 192: 43.12
+	Ce
		711459 SEM5_CAEEL (1-216): 5.16e-61: 192: 57.60		Q23158_CAEEL (1009-1116): 1.02e-46: 184: 40.37
+	Hs
		773152 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH10_HUMAN (227-1075): 8.57e-32: 137: 10.87
+	Hs
		584555 VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37		CYTSA_HUMAN (1-1117): 2.93e-74: 269: 100.00
+	Hs
		772723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH9_HUMAN (578-1049): 1.31e-13: 78: 12.21
+	Hs
		1061512 PTK6_HUMAN (4-141): 7.17e-23: 97.1: 38.93		ACTN3_HUMAN (1009-1115): 7.89e-51: 196: 40.74
+	Hs
		776799 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH11_HUMAN (600-1054): 6.14e-13: 75.7: 9.76
+	Hs
		987689 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CYTSB_HUMAN (121-509): 6.43e-12: 72.2: 10.28
+	Hs
		555588 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		ACTN1_HUMAN (1009-1116): 3.98e-50: 194: 42.20
+	Hs
		224602 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		ACTN4_HUMAN (1009-1116): 6.69e-48: 187: 41.28
+	Hs
		557552 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		MYH4_HUMAN (199-1033): 2.96e-32: 138: 9.91
+	Hs
		440414 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MYH9_HUMAN (578-1049): 1.31e-13: 78: 12.21
+	Hs
		117127 J3QRU1_HUMAN (71-215): 6.6e-12: 65.8: 16.33		MYH9_HUMAN (578-1049): 1.31e-13: 78: 12.21
+	Hs
		463006 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		MYH9_HUMAN (578-1049): 1.31e-13: 78: 12.21
+	Hs
		463646 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		MILK1_HUMAN (1014-1115): 3.08e-15: 82.8: 42.72
+	Hs
		463377 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		MYH9_HUMAN (578-1049): 1.31e-13: 78: 12.21
+	Hs
		1154097 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		CYTSB_HUMAN (121-509): 6.43e-12: 72.2: 10.28
+	Hs
		463565 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		CYTSB_HUMAN (121-509): 6.43e-12: 72.2: 10.28