HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ASAP3 (Q8TDY4)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)
Gene: ASAP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, PH~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 903
+	Hs
		207918 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ASAP2_HUMAN (1-677): 5.83e-152: 475: 53.13
+	Hs
		988022 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ASAP1_HUMAN (1-679): 7.13e-143: 454: 48.18
+	Hs
		207910 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ASAP2_HUMAN (1-677): 5.83e-152: 475: 53.13
+	Hs
		594133 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ASAP1_HUMAN (1-679): 7.13e-143: 454: 48.18
+	Hs
		362407 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		ASAP1_HUMAN (1-679): 7.13e-143: 454: 48.18
+	Hs
		207903 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		ASAP2_HUMAN (1-677): 5.83e-152: 475: 53.13
+	Hs
		207904 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		ASAP2_HUMAN (1-677): 5.83e-152: 475: 53.13
+	Hs
		207922 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		ASAP2_HUMAN (1-677): 5.83e-152: 475: 53.13
+	Hs
		440782 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		ASAP1_HUMAN (1-679): 7.13e-143: 454: 48.18
+	Hs
		473483 HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90		ASAP1_HUMAN (1-679): 7.13e-143: 454: 48.18
+	Hs
		987887 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CYH2_HUMAN (43-395): 6.26e-66: 228: 12.53
+	Hs
		987873 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ARAP1_HUMAN (222-585): 4.31e-52: 200: 20.89
+	Mm
		73887 B2RQ57_MOUSE (4-139): 1.45e-20: 91.3: 33.33		AGAP2_MOUSE (357-645): 9.8e-80: 283: 30.41
+	Hs
		440051 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		ANK3_HUMAN (386-806): 3.39e-56: 214: 9.32
+	Hs
		440161 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		ARAP2_HUMAN (117-585): 1.9e-55: 211: 19.20
+	Hs
		594083 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ARAP1_HUMAN (222-585): 4.31e-52: 200: 20.89
+	Hs
		987649 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ACAP1_HUMAN (708-806): 1.38e-09: 63.9: 6.86
+	Hs
		440655 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		ARAP2_HUMAN (117-585): 1.9e-55: 211: 19.20
+	Hs
		594002 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ACAP1_HUMAN (708-806): 1.38e-09: 63.9: 6.86
+	Hs
		362293 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		ACAP1_HUMAN (708-806): 1.38e-09: 63.9: 6.86