Protein: CYH2
Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)

Gene: CYH2, CYTH2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q99418

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1359655

ICEF1
Interactor protein for cytohesin exchange factors 1

5

20

Small-scale

0.936

High

1380307

CNKR1
Connector enhancer of kinase suppressor of ras 1

4

18

High-throughput

0.902

High

1014948

ARF1
ADP-ribosylation factor 1

4

14

Small-scale

0.885

High

975195

ARF6
ADP-ribosylation factor 6

3

15

Small-scale

0.840

High

1392978

CC120
Coiled-coil domain-containing protein 120

8

11

High-throughput

0.755

High

886308

ARL4D
ADP-ribosylation factor-like protein 4D

1

20

Small-scale

0.740

High

1186184

INAVA
Innate immunity activator protein

6

11

Small-scale

0.733

High

1149061

CYH1
Cytohesin-1

1

9

High-throughput

0.691

High

1122814

DOCK1
Dedicator of cytokinesis protein 1

1

0

Small-scale

0.687

High

255529

CYTIP
Cytohesin-interacting protein

3

17

High-throughput

0.667

High

783385

TRI23
E3 ubiquitin-protein ligase TRIM23

1

20

Small-scale

0.647

High

439833

INSR
Insulin receptor

1

7

Small-scale

0.646

High

772519

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.646

High

1194666

CCD40
Coiled-coil domain-containing protein 40

2

3

High-throughput

0.628

High

1161191

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.622

High

827304

ARL4A
ADP-ribosylation factor-like protein 4A

1

20

Small-scale

0.621

High

987887

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.618

High

584138

FOSL2
Fos-related antigen 2

3

7

High-throughput

0.609

High

239181

ZNRD2
Protein ZNRD2

2

2

High-throughput

0.601

High

1049702

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1199942

P5CR3
Pyrroline-5-carboxylate reductase 3

2

2

High-throughput

0.601

High

1404085

ATIF1
ATPase inhibitor, mitochondrial

2

1

High-throughput

0.601

High

1404088

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

4

Small-scale

0.595

High

709252

AA2AR
Adenosine receptor A2a

1

1

Small-scale

0.586

High

732680

ARRB2
Beta-arrestin-2

1

3

Small-scale

0.561

High

882551

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.561

High

893523

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

4

Small-scale

0.561

High

1382801

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

2

Small-scale

0.552

High

668701

APC
Adenomatous polyposis coli protein

1

3

High-throughput

0.541

High

167524

TX1B3
Tax1-binding protein 3

1

10

High-throughput

0.536

High

1066007

VAC14
Protein VAC14 homolog

1

3

High-throughput

0.536

High

1404089

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

730848

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1404086

STRP2
Striatin-interacting protein 2

1

0

High-throughput

0.513

High

1404082

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.512

High

1106809

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

4

Small-scale

0.501

High

1371955

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

4

Small-scale

0.501

High

1404083

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

4

Small-scale

0.501

High

791649

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

839076

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

Small-scale

0.481

High

402665

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.480

High

973545

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

1141885

EEA1
Early endosome antigen 1

1

2

High-throughput

0.479

High

1404087

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

1

High-throughput

0.479

High

1347766

STML3
Stomatin-like protein 3

1

0

High-throughput

0.458

High

1404084

GGA3
ADP-ribosylation factor-binding protein GGA3

1

1

Small-scale

0.457

High

424096

ITB2
Integrin beta-2

1

1

Small-scale

0.457

High

1400116

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

6

High-throughput

0.445

High


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Last updated: 11Aug2025