HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: AUTS2 (Q8WXX7)
Autism susceptibility gene 2 protein
Gene: AUTS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25519132, 27705803
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 1259
+	Hs
		1264228 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00
+	Mm
		397 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		AUTS2_MOUSE (1-1259): 7.09e-133: 440: 90.25
+	Mm
		193409 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01
+	Mm
		1161099 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01
+	Hs
		988026 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03
+	Hs
		988023 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54
+	Hs
		1304118 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03
+	Hs
		111280 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		J3KNZ9_HUMAN (480-885): 7.73e-30: 130: 39.22
+	Hs
		1304115 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54
+	Hs
		987995 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		KMT2C_HUMAN (430-1258): 3.63e-13: 77: 9.23
+	Hs
		554277 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		MUC1_HUMAN (21-960): 4.41e-54: 209: 12.26
+	Hs
		988011 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		1300908 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		1264788 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		TITIN_HUMAN (60-591): 1.15e-09: 65.3: 11.92
+	Hs
		718208 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54
+	Hs
		718429 PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37		FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54
+	Hs
		718055 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		TITIN_HUMAN (60-591): 1.15e-09: 65.3: 11.92
+	Hs
		1223393 TRI22_HUMAN (41-392): 2.66e-43: 159: 10.50		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		1223389 TRI22_HUMAN (41-392): 2.66e-43: 159: 10.50		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		585039 RO52_HUMAN (33-392): 4.67e-43: 158: 13.14		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34