HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 282
+	Hs
		1111853 TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Hs
		988088 TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1029573 PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1451085 RBM22_HUMAN (2-287): 1.83e-33: 128: 15.91		PPIE_HUMAN (16-102): 3.37e-32: 122: 35.63
+	Hs
		988235 TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00		PPIE_HUMAN (16-102): 3.37e-32: 122: 35.63
+	Hs
		1090289 ELAV2_HUMAN (52-244): 5.96e-24: 101: 20.00		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Hs
		1090218 TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		1090307 RBM22_HUMAN (2-287): 1.83e-33: 128: 15.91		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		1101941 TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		988100 TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		550269 TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Ce
		1457937 Q9U2S6_CAEEL (118-203): 1.62e-24: 102: 35.56		Q9U2S6_CAEEL (9-102): 1.19e-30: 118: 28.72
+	Hs
		550217 TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Mm
		915277 TRA2B_MOUSE (1-267): 1.08e-33: 126: 100.00		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		1090322 PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		686613 ELAV4_HUMAN (52-261): 1.01e-24: 103: 17.93		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		550522 PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		1090216 ELAV2_HUMAN (52-244): 5.96e-24: 101: 20.00		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		550250 ELAV2_HUMAN (52-244): 5.96e-24: 101: 20.00		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63