HitPredict

Interactor 1: PP1G (P63087)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: Ppp1cc

Interactor 2: MYPT1 (Q9DBR7)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1)
Gene: Ppp1r12a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22544752
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0005730 - nucleolus GO:0019901 - protein kinase binding GO:0046822 - regulation of nucleocytoplasmic transport GO:0072357 - PTW/PP1 phosphatase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Mm			1 1029
+	Hs
		171191 PP1G_HUMAN (1-323): 0: 601: 99.69		MYPT1_HUMAN (1-1029): 5.19e-135: 435: 92.14
+	Mm
		968206 PP1A_MOUSE (1-323): 0: 578: 90.36		MYPT1_MOUSE (1-1029): 3.45e-137: 440: 100.00
+	Hs
		171216 PP1A_HUMAN (1-323): 0: 578: 90.66		MYPT1_HUMAN (1-1029): 5.19e-135: 435: 92.14
+	Hs
		171217 PP1B_HUMAN (1-322): 0: 559: 86.89		MYPT1_HUMAN (1-1029): 5.19e-135: 435: 92.14
+	Gg
		969133 PP1B_CHICK (1-322): 0: 559: 86.89		MYPT1_CHICK (1-984): 1.75e-104: 352: 79.34
+	Hs
		786782 PP1G_HUMAN (1-323): 0: 601: 99.69		PP16A_HUMAN (2-490): 3.02e-82: 278: 26.19
+	Hs
		967914 PP1A_HUMAN (1-323): 0: 578: 90.66		PP16A_HUMAN (2-490): 3.02e-82: 278: 26.19
+	Hs
		786804 PP1G_HUMAN (1-323): 0: 601: 99.69		PP16B_HUMAN (2-517): 2.05e-70: 247: 25.60
+	Hs
		968408 PP1B_HUMAN (1-322): 0: 559: 86.89		PP16A_HUMAN (2-490): 3.02e-82: 278: 26.19
+	Hs
		967936 PP1A_HUMAN (1-323): 0: 578: 90.66		PP16B_HUMAN (2-517): 2.05e-70: 247: 25.60
+	Hs
		3398 PP1B_HUMAN (1-322): 0: 559: 86.89		A0A0S2Z4Q8_HUMAN (2-163): 2.92e-61: 208: 64.91
+	Hs
		786829 PP1G_HUMAN (1-323): 0: 601: 99.69		PP12C_HUMAN (528-1029): 1.72e-31: 134: 23.51
+	Hs
		967953 PP1A_HUMAN (1-323): 0: 578: 90.66		PP12C_HUMAN (528-1029): 1.72e-31: 134: 23.51
+	Hs
		239304 PP1G_HUMAN (1-323): 0: 601: 99.69		MYPT2_HUMAN (1-909): 1.77e-23: 109: 11.55
+	Hs
		239307 PP1A_HUMAN (1-323): 0: 578: 90.66		MYPT2_HUMAN (1-909): 1.77e-23: 109: 11.55
+	Mm
		968132 PP1A_MOUSE (1-323): 0: 578: 90.36		MYPT2_MOUSE (1-909): 3.12e-23: 108: 10.64
+	Hs
		239308 PP1B_HUMAN (1-322): 0: 559: 86.89		MYPT2_HUMAN (1-909): 1.77e-23: 109: 11.55
+	Hs
		967833 PP1A_HUMAN (1-323): 0: 578: 90.66		PPR27_HUMAN (36-152): 1.42e-18: 85.5: 39.83
+	Mm
		968091 PP1A_MOUSE (1-323): 0: 578: 90.36		PP12C_MOUSE (1-146): 1.75e-15: 83.4: 19.54
+	Hs
		968362 PP1B_HUMAN (1-322): 0: 559: 86.89		PPR27_HUMAN (36-152): 1.42e-18: 85.5: 39.83