HitPredict

Interactor 1: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 7797570, 17353931
Identification Methods pull down, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains G-alpha~G-alpha
Common GO terms GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0003091 - renal water homeostasis
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
and 29 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 394
Hs

1 394
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025