HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: FBX6 (Q9NRD1)
F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)
Gene: FBXO6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	32409323, 22268729
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4544 Hs			1 293
+	Hs
		1269027 SORL_HUMAN (4091-4375): 6.29e-11: 71.4: 12.95		FBX6_HUMAN (1-293): 1.15e-178: 495: 100.00
+	Hs
		351107 LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95		FBX6_HUMAN (1-293): 1.15e-178: 495: 100.00
+	Hs
		980571 NOTC2_HUMAN (2441-2811): 3.71e-13: 79.1: 10.70		FBX2_HUMAN (23-259): 3.78e-119: 345: 49.17
+	Hs
		1048430 NID2_HUMAN (1679-1844): 5.93e-11: 71.4: 24.86		FBX2_HUMAN (23-259): 3.78e-119: 345: 49.17
+	Hs
		1269038 SORL_HUMAN (4091-4375): 6.29e-11: 71.4: 12.95		FBX2_HUMAN (23-259): 3.78e-119: 345: 49.17
+	Hs
		957659 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		FBX2_HUMAN (23-259): 3.78e-119: 345: 49.17
+	Hs
		1349415 LRP1B_HUMAN (2-280): 8.74e-09: 64.5: 16.93		FBX2_HUMAN (23-259): 3.78e-119: 345: 49.17