HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: SOX17 (Q9H6I2)
Transcription factor SOX-17
Gene: SOX17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0016055 - Wnt signaling pathway GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 414
+	Hs
		980649 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX17_HUMAN (1-414): 2.23e-53: 184: 100.00
+	Hs
		980847 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		CIC_HUMAN (10-295): 3.85e-44: 166: 19.66
+	Hs
		727850 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX6_HUMAN (46-219): 3.19e-36: 142: 35.36
+	Hs
		727732 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX5_HUMAN (39-195): 5.11e-34: 136: 33.33
+	Hs
		817954 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX2_HUMAN (36-340): 1.52e-33: 129: 27.33
+	Hs
		727851 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SOX6_HUMAN (46-219): 3.19e-36: 142: 35.36
+	Hs
		881797 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX10_HUMAN (33-393): 3.12e-31: 126: 24.81
+	Hs
		980882 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TF7L2_HUMAN (9-322): 6.87e-36: 140: 18.52
+	Hs
		980642 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX7_HUMAN (27-411): 1.19e-28: 117: 35.86
+	Hs
		817955 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SOX2_HUMAN (36-340): 1.52e-33: 129: 27.33
+	Hs
		818792 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX9_HUMAN (4-378): 4.41e-24: 106: 25.00
+	Hs
		980859 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SOX7_HUMAN (27-411): 1.19e-28: 117: 35.86
+	Hs
		993616 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		TF7L2_HUMAN (9-322): 6.87e-36: 140: 18.52
+	Hs
		727734 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SOX5_HUMAN (39-195): 5.11e-34: 136: 33.33
+	Hs
		225730 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		SOX15_HUMAN (53-144): 3.74e-20: 90.5: 55.44
+	Hs
		817967 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SOX2_HUMAN (36-340): 1.52e-33: 129: 27.33
+	Hs
		225731 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		SOX15_HUMAN (53-144): 3.74e-20: 90.5: 55.44
+	Hs
		225733 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		SOX15_HUMAN (53-144): 3.74e-20: 90.5: 55.44
+	Dm
		558375 GROU_DROME (2-163): 3.54e-59: 198: 54.44		DICH_DROME (14-217): 1.01e-31: 125: 31.37
+	Dm
		558368 GROU_DROME (2-163): 3.54e-59: 198: 54.44		PANG1_DROME (15-296): 1.17e-25: 111: 14.48